The article reviews the role of liquid–liquid phase separation (LLPS) in Alzheimer’s disease (AD), focusing on the impact of metal ions, small-molecule inhibitors, and proteinaceous partners on tau LLPS and aggregation, as well as toxic oligomerization. It also discusses the role of LLPS in Aβ aggregation and the cross-interactions between amyloidogenic proteins in AD. The review highlights the significance of LLPS in AD pathogenesis, emphasizing its potential as a therapeutic target. Key findings include the involvement of LLPS in the formation of tau droplets and the transition of these droplets into aggregates, which are hallmarks of AD. The article also introduces the methods used in LLPS studies and provides insights into the broader implications of LLPS in various human diseases.The article reviews the role of liquid–liquid phase separation (LLPS) in Alzheimer’s disease (AD), focusing on the impact of metal ions, small-molecule inhibitors, and proteinaceous partners on tau LLPS and aggregation, as well as toxic oligomerization. It also discusses the role of LLPS in Aβ aggregation and the cross-interactions between amyloidogenic proteins in AD. The review highlights the significance of LLPS in AD pathogenesis, emphasizing its potential as a therapeutic target. Key findings include the involvement of LLPS in the formation of tau droplets and the transition of these droplets into aggregates, which are hallmarks of AD. The article also introduces the methods used in LLPS studies and provides insights into the broader implications of LLPS in various human diseases.