This study evaluates the long-term clinical outcomes of 3D-printed subperiosteal titanium implants in edentulous patients with atrophic alveolar bone. The research involved 36 patients (61 implants) over a 6-year follow-up period. The implants were designed using DentalCAD 3.0 Galway software and fabricated with Mysint 100 titanium alloy powder. The results showed that only 9 out of 36 cases were successful, while 27 cases experienced complications, including metal frame exposure, device mobility, and recurrent infections. The study concludes that while fully customized subperiosteal jaw implants can be a dependable alternative for dental rehabilitation in atrophic edentulous cases, their prudent application is crucial due to the high failure rate and complications. The findings highlight the need for further research to improve the biocompatibility and design of these implants.This study evaluates the long-term clinical outcomes of 3D-printed subperiosteal titanium implants in edentulous patients with atrophic alveolar bone. The research involved 36 patients (61 implants) over a 6-year follow-up period. The implants were designed using DentalCAD 3.0 Galway software and fabricated with Mysint 100 titanium alloy powder. The results showed that only 9 out of 36 cases were successful, while 27 cases experienced complications, including metal frame exposure, device mobility, and recurrent infections. The study concludes that while fully customized subperiosteal jaw implants can be a dependable alternative for dental rehabilitation in atrophic edentulous cases, their prudent application is crucial due to the high failure rate and complications. The findings highlight the need for further research to improve the biocompatibility and design of these implants.