A 6-year follow-up study evaluated the clinical outcomes of 3D-printed subperiosteal titanium implants in 36 patients with edentulous or partially edentulous jaws. The study aimed to assess the effectiveness of these implants, which require minimal bone preparation and allow for rapid prosthetic tooth placement. The implants were designed using the Exoplan 3.0 Galway software and fabricated with a DMLS system using titanium alloy powder. The results showed that only 9 out of 36 cases were successful at the 6-year follow-up, while 27 cases experienced complications, including metal frame exposure, device mobility, and recurrent infections. One case failed due to reasons unrelated to the implant. The study concluded that while 3D-printed subperiosteal implants offer a potential alternative for dental rehabilitation in atrophic edentulous cases requiring bone grafts, their long-term success is limited due to complications such as exposure, infection, and mobility. The study highlights the need for further research to improve the design and application of these implants. The survival rate at 6 years was 45.9%, with 9 patients showing no complications and 12 under observation. The study also noted that early complications occurred in 67.2% of cases, while late complications were present in 68.4% of cases. The results indicate that while these implants can be effective, their long-term success is not guaranteed, and further research is needed to optimize their design and application.A 6-year follow-up study evaluated the clinical outcomes of 3D-printed subperiosteal titanium implants in 36 patients with edentulous or partially edentulous jaws. The study aimed to assess the effectiveness of these implants, which require minimal bone preparation and allow for rapid prosthetic tooth placement. The implants were designed using the Exoplan 3.0 Galway software and fabricated with a DMLS system using titanium alloy powder. The results showed that only 9 out of 36 cases were successful at the 6-year follow-up, while 27 cases experienced complications, including metal frame exposure, device mobility, and recurrent infections. One case failed due to reasons unrelated to the implant. The study concluded that while 3D-printed subperiosteal implants offer a potential alternative for dental rehabilitation in atrophic edentulous cases requiring bone grafts, their long-term success is limited due to complications such as exposure, infection, and mobility. The study highlights the need for further research to improve the design and application of these implants. The survival rate at 6 years was 45.9%, with 9 patients showing no complications and 12 under observation. The study also noted that early complications occurred in 67.2% of cases, while late complications were present in 68.4% of cases. The results indicate that while these implants can be effective, their long-term success is not guaranteed, and further research is needed to optimize their design and application.