Long-term potentiation (LTP) is a form of synaptic plasticity that is thought to underlie memory formation. This review discusses the role of LTP in memory, focusing on the hippocampus and its connections to other brain regions. The hippocampus is essential for spatial memory, and studies have shown that damage to the hippocampus impairs spatial learning. LTP is induced by high-frequency stimulation and is dependent on NMDA receptor activation. It is also involved in learning and memory, and its mechanisms involve calcium influx, CaMKII activation, and protein synthesis. The review also discusses the role of other brain regions, such as the amygdala, visual cortex, and prefrontal cortex, in supporting LTP and memory. The review highlights the importance of synaptic plasticity in memory formation and the role of various signaling pathways, including cAMP, ERK, and CREB, in LTP. It also discusses the effects of stress on LTP and memory, and the role of neurotrophins in memory and LTP. The review concludes that LTP and memory share cellular mechanisms, and that understanding these mechanisms is crucial for understanding learning and memory.Long-term potentiation (LTP) is a form of synaptic plasticity that is thought to underlie memory formation. This review discusses the role of LTP in memory, focusing on the hippocampus and its connections to other brain regions. The hippocampus is essential for spatial memory, and studies have shown that damage to the hippocampus impairs spatial learning. LTP is induced by high-frequency stimulation and is dependent on NMDA receptor activation. It is also involved in learning and memory, and its mechanisms involve calcium influx, CaMKII activation, and protein synthesis. The review also discusses the role of other brain regions, such as the amygdala, visual cortex, and prefrontal cortex, in supporting LTP and memory. The review highlights the importance of synaptic plasticity in memory formation and the role of various signaling pathways, including cAMP, ERK, and CREB, in LTP. It also discusses the effects of stress on LTP and memory, and the role of neurotrophins in memory and LTP. The review concludes that LTP and memory share cellular mechanisms, and that understanding these mechanisms is crucial for understanding learning and memory.