Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not code for proteins. They play a significant role in cancer, with many lncRNAs involved in regulating gene expression and cancer progression. This review discusses the classification of lncRNAs, their functions, and their potential applications in cancer research and treatment. LncRNAs are categorized into various types, including long intergenic non-coding RNAs (lincRNAs), antisense transcripts, and promoter upstream transcripts (PROMPTs). They can influence cancer by modulating chromatin structure, gene expression, and transcriptional activity. LncRNAs have been linked to various cancers, and their expression levels are often altered in cancerous tissues compared to normal tissues. Some lncRNAs act as miRNA decoys, sequestering miRNAs and affecting their function. LncRNAs may also serve as biomarkers for cancer diagnosis and prognosis. Additionally, they could be used as therapeutic agents, either directly or through gene therapy. The review highlights the importance of lncRNAs in cancer research and their potential for future clinical applications.Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not code for proteins. They play a significant role in cancer, with many lncRNAs involved in regulating gene expression and cancer progression. This review discusses the classification of lncRNAs, their functions, and their potential applications in cancer research and treatment. LncRNAs are categorized into various types, including long intergenic non-coding RNAs (lincRNAs), antisense transcripts, and promoter upstream transcripts (PROMPTs). They can influence cancer by modulating chromatin structure, gene expression, and transcriptional activity. LncRNAs have been linked to various cancers, and their expression levels are often altered in cancerous tissues compared to normal tissues. Some lncRNAs act as miRNA decoys, sequestering miRNAs and affecting their function. LncRNAs may also serve as biomarkers for cancer diagnosis and prognosis. Additionally, they could be used as therapeutic agents, either directly or through gene therapy. The review highlights the importance of lncRNAs in cancer research and their potential for future clinical applications.