This review focuses on long non-coding RNAs (lncRNAs) and their role in cancer. It defines lncRNAs, presents a list of cancer-related lncRNAs, and discusses the functions and genetic mechanisms underlying lncRNA expression changes in cancer. The review also highlights the potential applications of lncRNA research in cancer diagnosis, prognosis, and therapy. Key findings include the identification of lncRNAs that are upregulated or downregulated in cancer, their involvement in chromatin regulation, and their potential as biomarkers and therapeutic targets. The review emphasizes the need for further research to fully understand the role of lncRNAs in cancer and to develop clinical applications.This review focuses on long non-coding RNAs (lncRNAs) and their role in cancer. It defines lncRNAs, presents a list of cancer-related lncRNAs, and discusses the functions and genetic mechanisms underlying lncRNA expression changes in cancer. The review also highlights the potential applications of lncRNA research in cancer diagnosis, prognosis, and therapy. Key findings include the identification of lncRNAs that are upregulated or downregulated in cancer, their involvement in chromatin regulation, and their potential as biomarkers and therapeutic targets. The review emphasizes the need for further research to fully understand the role of lncRNAs in cancer and to develop clinical applications.