The study investigates the role of extracellular matrix (ECM) composition changes in healthy aging using C. elegans. It identifies three distinct collagen dynamics during aging: Pattern I collagens decline in expression and protein levels, Pattern II collagens remain incorporated into the ECM, and Pattern III collagens are continuously synthesized and thicken the ECM. Longevity interventions, such as reducing insulin/IGF-1 receptor signaling (rIIS), slow the loss of Pattern I collagens and prolong the expression of collagens that are turned over. These interventions are mediated by a mechanical feedback loop involving hemidesmosome-containing structures that span from the exoskeletal ECM to the muscles, coupling mechanical forces to adjust ECM gene expression and longevity via the transcriptional co-activator YAP-1. The results provide in vivo evidence that coordinated ECM remodeling through mechanotransduction is essential for promoting longevity, offering potential avenues for interventions targeting ECM dynamics.The study investigates the role of extracellular matrix (ECM) composition changes in healthy aging using C. elegans. It identifies three distinct collagen dynamics during aging: Pattern I collagens decline in expression and protein levels, Pattern II collagens remain incorporated into the ECM, and Pattern III collagens are continuously synthesized and thicken the ECM. Longevity interventions, such as reducing insulin/IGF-1 receptor signaling (rIIS), slow the loss of Pattern I collagens and prolong the expression of collagens that are turned over. These interventions are mediated by a mechanical feedback loop involving hemidesmosome-containing structures that span from the exoskeletal ECM to the muscles, coupling mechanical forces to adjust ECM gene expression and longevity via the transcriptional co-activator YAP-1. The results provide in vivo evidence that coordinated ECM remodeling through mechanotransduction is essential for promoting longevity, offering potential avenues for interventions targeting ECM dynamics.