July 2005 | Bruce P. Lanphear, Richard Hornung, Jane Khoury, Kimberly Yolton, Peter Baghurst, David C. Bellinger, Richard L. Canfield, Kim N. Dietrich, Robert Bornschein, Tom Greene, Stephen J. Rothenberg, Herbert L. Needleman, Lourdes Schnaas, Gail Wasserman, Joseph Graziano, Russell Roberts
This study examines the association between low-level environmental lead exposure and children's intellectual function, focusing on children with maximal blood lead levels below 10 μg/dL. Data from seven international longitudinal cohort studies were pooled to analyze the relationship between intelligence test scores and blood lead concentration. The primary outcome measure was the full-scale IQ score, which was significantly related to concurrent blood lead levels. The results showed an inverse relationship between blood lead concentration and IQ score, with a 6.9 IQ point decrement associated with an increase in concurrent blood lead levels from 2.4 to 30 μg/dL. The lead-associated IQ decrement was greater for children with maximal blood lead levels below 7.5 μg/dL compared to those with higher levels. The study concludes that environmental lead exposure in children with maximal blood lead levels below 7.5 μg/dL is associated with intellectual deficits, emphasizing the importance of primary prevention to reduce lead exposure.This study examines the association between low-level environmental lead exposure and children's intellectual function, focusing on children with maximal blood lead levels below 10 μg/dL. Data from seven international longitudinal cohort studies were pooled to analyze the relationship between intelligence test scores and blood lead concentration. The primary outcome measure was the full-scale IQ score, which was significantly related to concurrent blood lead levels. The results showed an inverse relationship between blood lead concentration and IQ score, with a 6.9 IQ point decrement associated with an increase in concurrent blood lead levels from 2.4 to 30 μg/dL. The lead-associated IQ decrement was greater for children with maximal blood lead levels below 7.5 μg/dL compared to those with higher levels. The study concludes that environmental lead exposure in children with maximal blood lead levels below 7.5 μg/dL is associated with intellectual deficits, emphasizing the importance of primary prevention to reduce lead exposure.