In a study of four infants exposed to hypoxia during air travel, hypoxia was discontinued as soon as possible when their oxygen saturation dropped to ≤80%. No infant remained at this level for more than 126 seconds. One infant had a sibling who died of sudden infant death syndrome (SIDS) and was being monitored at home. All four infants had normal oxygen saturation levels during subsequent monitoring. The researchers believed that prolonged hospital monitoring would not be ethically appropriate due to potential additional risks. The two infants who died after the flight were not monitored, so their exposure to hypoxia is unknown. The study aimed to assess the effects of folic acid and vitamin B-12 on blood homocysteine levels. A meta-analysis of 12 randomized trials showed that folic acid reduced homocysteine by 25% (95% CI 23-28%), with similar effects at 0.5-5 mg daily. Vitamin B-12 added 7% (3-10%) reduction, while B-6 had no significant effect. In typical Western populations, daily supplementation with 0.5-5 mg folic acid and 0.5 mg B-12 would reduce homocysteine by about a quarter to a third. Large-scale trials are needed to determine if lowering homocysteine reduces vascular disease risk. The study found that higher pretreatment homocysteine and lower folate levels increased the reduction in homocysteine with folic acid. The effect was consistent across different doses of folic acid. Vitamin B-12 provided a small additional benefit, while B-6 had no effect. The results suggest that folic acid supplementation could be a cost-effective method to lower homocysteine levels, potentially reducing vascular disease risk. However, further research is needed to confirm these findings and assess long-term benefits.In a study of four infants exposed to hypoxia during air travel, hypoxia was discontinued as soon as possible when their oxygen saturation dropped to ≤80%. No infant remained at this level for more than 126 seconds. One infant had a sibling who died of sudden infant death syndrome (SIDS) and was being monitored at home. All four infants had normal oxygen saturation levels during subsequent monitoring. The researchers believed that prolonged hospital monitoring would not be ethically appropriate due to potential additional risks. The two infants who died after the flight were not monitored, so their exposure to hypoxia is unknown. The study aimed to assess the effects of folic acid and vitamin B-12 on blood homocysteine levels. A meta-analysis of 12 randomized trials showed that folic acid reduced homocysteine by 25% (95% CI 23-28%), with similar effects at 0.5-5 mg daily. Vitamin B-12 added 7% (3-10%) reduction, while B-6 had no significant effect. In typical Western populations, daily supplementation with 0.5-5 mg folic acid and 0.5 mg B-12 would reduce homocysteine by about a quarter to a third. Large-scale trials are needed to determine if lowering homocysteine reduces vascular disease risk. The study found that higher pretreatment homocysteine and lower folate levels increased the reduction in homocysteine with folic acid. The effect was consistent across different doses of folic acid. Vitamin B-12 provided a small additional benefit, while B-6 had no effect. The results suggest that folic acid supplementation could be a cost-effective method to lower homocysteine levels, potentially reducing vascular disease risk. However, further research is needed to confirm these findings and assess long-term benefits.