Luteolin, a flavonoid found in many plants, has potential for cancer prevention and therapy. It exhibits multiple biological effects, including anti-inflammatory, anti-allergic, and anticancer properties. Luteolin functions as either an antioxidant or a pro-oxidant, and its anticancer activity is linked to inducing apoptosis, inhibiting cell proliferation, metastasis, and angiogenesis. It also sensitizes cancer cells to therapeutic-induced cytotoxicity by suppressing survival pathways like PI3K/Akt, NF-κB, and XIAP, while stimulating apoptosis pathways such as those involving p53. Recent studies suggest luteolin has cancer-preventive properties. Luteolin's antioxidant activity involves scavenging ROS, inhibiting ROS-generating oxidases, and protecting endogenous antioxidants. It may also have pro-oxidant effects, depending on concentration and cellular context. Luteolin's estrogenic activity may be beneficial for hormone replacement therapy, but it can also have anti-estrogenic effects by competing with estrogens for binding to ERs or inhibiting aromatase. Luteolin exhibits anti-inflammatory effects by suppressing cytokine production and signaling pathways like NF-κB and MAPK. It inhibits cancer cell proliferation by regulating the cell cycle, suppressing growth factor signaling, and inducing apoptosis. Luteolin induces apoptosis in cancer cells through various mechanisms, including activating death receptors and mitochondrial pathways. It also suppresses angiogenesis by inhibiting VEGF and MMPs. Luteolin may prevent metastasis by inhibiting cytokine production and signaling pathways involved in migration and invasion. Luteolin shows promise as an anticancer agent and chemopreventive agent, with in vivo studies supporting its efficacy in reducing tumor growth and incidence. Combination therapy with luteolin and other anticancer drugs enhances therapeutic effectiveness. Luteolin is relatively safe, but further studies are needed to confirm its safety and efficacy in humans. Epidemiological studies suggest dietary intake of luteolin may reduce cancer risk. Overall, luteolin's diverse biological activities and potential for cancer prevention and therapy make it a promising candidate for further research and clinical application.Luteolin, a flavonoid found in many plants, has potential for cancer prevention and therapy. It exhibits multiple biological effects, including anti-inflammatory, anti-allergic, and anticancer properties. Luteolin functions as either an antioxidant or a pro-oxidant, and its anticancer activity is linked to inducing apoptosis, inhibiting cell proliferation, metastasis, and angiogenesis. It also sensitizes cancer cells to therapeutic-induced cytotoxicity by suppressing survival pathways like PI3K/Akt, NF-κB, and XIAP, while stimulating apoptosis pathways such as those involving p53. Recent studies suggest luteolin has cancer-preventive properties. Luteolin's antioxidant activity involves scavenging ROS, inhibiting ROS-generating oxidases, and protecting endogenous antioxidants. It may also have pro-oxidant effects, depending on concentration and cellular context. Luteolin's estrogenic activity may be beneficial for hormone replacement therapy, but it can also have anti-estrogenic effects by competing with estrogens for binding to ERs or inhibiting aromatase. Luteolin exhibits anti-inflammatory effects by suppressing cytokine production and signaling pathways like NF-κB and MAPK. It inhibits cancer cell proliferation by regulating the cell cycle, suppressing growth factor signaling, and inducing apoptosis. Luteolin induces apoptosis in cancer cells through various mechanisms, including activating death receptors and mitochondrial pathways. It also suppresses angiogenesis by inhibiting VEGF and MMPs. Luteolin may prevent metastasis by inhibiting cytokine production and signaling pathways involved in migration and invasion. Luteolin shows promise as an anticancer agent and chemopreventive agent, with in vivo studies supporting its efficacy in reducing tumor growth and incidence. Combination therapy with luteolin and other anticancer drugs enhances therapeutic effectiveness. Luteolin is relatively safe, but further studies are needed to confirm its safety and efficacy in humans. Epidemiological studies suggest dietary intake of luteolin may reduce cancer risk. Overall, luteolin's diverse biological activities and potential for cancer prevention and therapy make it a promising candidate for further research and clinical application.