This review examines the potential of luteolin, a flavonoid, in treating neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and multiple sclerosis (MS). Luteolin has shown significant anti-inflammatory, antioxidant, and neuroprotective properties, making it a promising candidate for adjuvant therapy in these conditions. Preclinical studies have demonstrated that luteolin can inhibit inflammatory pathways, reduce oxidative stress, and protect neurons from apoptosis. In AD, luteolin has been found to inhibit Aβ-induced toxicity, reduce microglial and astrocytic inflammation, and improve cognitive function. In PD, it has shown protective effects against MPP+-induced apoptosis and 6-OHDA-induced neurotoxicity. For HD, luteolin derivatives have exhibited neuroprotective activities and reduced oxidative stress. However, clinical evidence of luteolin's therapeutic efficacy remains limited, and further research is needed to validate its potential in treating neurodegenerative diseases.This review examines the potential of luteolin, a flavonoid, in treating neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and multiple sclerosis (MS). Luteolin has shown significant anti-inflammatory, antioxidant, and neuroprotective properties, making it a promising candidate for adjuvant therapy in these conditions. Preclinical studies have demonstrated that luteolin can inhibit inflammatory pathways, reduce oxidative stress, and protect neurons from apoptosis. In AD, luteolin has been found to inhibit Aβ-induced toxicity, reduce microglial and astrocytic inflammation, and improve cognitive function. In PD, it has shown protective effects against MPP+-induced apoptosis and 6-OHDA-induced neurotoxicity. For HD, luteolin derivatives have exhibited neuroprotective activities and reduced oxidative stress. However, clinical evidence of luteolin's therapeutic efficacy remains limited, and further research is needed to validate its potential in treating neurodegenerative diseases.