This study investigates the role and mechanism of action of M2 macrophage-derived exosomes (M2-exos) in angiogenesis after myocardial infarction (MI). M2-exos were harvested and injected intramyocardially at the onset of MI, and their effects on endothelial cells (ECs) were assessed. The results showed that M2-exos improved cardiac function, reduced infarct size, and enhanced angiogenesis. In vitro experiments demonstrated that M2-exos promoted angiogenesis by transporting miR-132-3p to ECs, which down-regulated the expression of *THBS1* through direct binding to its 3′UTR. The cardioprotective effects of M2-exos were largely reversed by *THBS1* overexpression. These findings highlight the role of M2-exos in cardiac repair and provide new insights into intercellular communication in post-infarction angiogenesis.This study investigates the role and mechanism of action of M2 macrophage-derived exosomes (M2-exos) in angiogenesis after myocardial infarction (MI). M2-exos were harvested and injected intramyocardially at the onset of MI, and their effects on endothelial cells (ECs) were assessed. The results showed that M2-exos improved cardiac function, reduced infarct size, and enhanced angiogenesis. In vitro experiments demonstrated that M2-exos promoted angiogenesis by transporting miR-132-3p to ECs, which down-regulated the expression of *THBS1* through direct binding to its 3′UTR. The cardioprotective effects of M2-exos were largely reversed by *THBS1* overexpression. These findings highlight the role of M2-exos in cardiac repair and provide new insights into intercellular communication in post-infarction angiogenesis.