This review article, authored by Yudong Yin and Richard G. Wunderink, focuses on the epidemiology, pathogenesis, clinical characteristics, and management of human coronavirus (HCoV) infections, particularly SARS-CoV and MERS-CoV. HCoVs have historically been considered relatively harmless respiratory pathogens, but the outbreaks of SARS and MERS have brought them into global attention as significant respiratory tract pathogens. The article highlights the transmission routes of SARS-CoV and MERS-CoV, including animal-to-human and human-to-human transmission, and discusses the clinical features, laboratory findings, and outcomes of these infections. It also reviews the diagnostic methods, including molecular detection, serology, and viral culture, and explores potential treatments such as ribavirin, interferons, and lopinavir/ritonavir. The authors emphasize the importance of further research to understand the pathogenesis of HCoV infections and to develop effective treatments.This review article, authored by Yudong Yin and Richard G. Wunderink, focuses on the epidemiology, pathogenesis, clinical characteristics, and management of human coronavirus (HCoV) infections, particularly SARS-CoV and MERS-CoV. HCoVs have historically been considered relatively harmless respiratory pathogens, but the outbreaks of SARS and MERS have brought them into global attention as significant respiratory tract pathogens. The article highlights the transmission routes of SARS-CoV and MERS-CoV, including animal-to-human and human-to-human transmission, and discusses the clinical features, laboratory findings, and outcomes of these infections. It also reviews the diagnostic methods, including molecular detection, serology, and viral culture, and explores potential treatments such as ribavirin, interferons, and lopinavir/ritonavir. The authors emphasize the importance of further research to understand the pathogenesis of HCoV infections and to develop effective treatments.