The article "MET signalling: principles and functions in development, organ regeneration and cancer" by Livio Trusolino, Andrea Bertotti, and Paolo M. Comoglio provides a comprehensive overview of the MET tyrosine kinase receptor and its roles in various biological processes. MET, also known as the HGF receptor, plays a crucial role in tissue remodelling, developmental morphogenesis, wound repair, organ homeostasis, and cancer metastasis. The versatility of MET-mediated responses is supported by qualitative and quantitative signal modulation, including the engagement of specific signal transducers and subcellular compartmentalization of signaling pathways. The authors discuss the molecular mechanisms underlying MET signaling, highlighting the importance of MET's interaction with various adaptor proteins and signal modifiers. They also explore how MET signaling influences different organismal functions in normal physiology and disease, emphasizing the need for a reconceptualization of these processes. The article further examines the causative relationships between individual signaling inputs and specific biological outputs in MET-driven processes, and provides insights into the medical implications of novel therapies that either promote or neutralize MET activity. In the context of embryonic development, MET and HGF are essential for the growth and survival of hepatocytes and placental trophoblast cells, as well as for the proliferation and motility of muscle progenitors. In organ regeneration, MET is crucial for liver and kidney regeneration, wound healing, and the regulation of fibrotic responses. In cancer, MET activation exacerbates the intrinsic malignant properties of transformed cells by conveying proliferative, anti-apoptotic, and pro-migratory signals. The article also discusses the potential therapeutic strategies based on targeting MET signaling in both regenerative medicine and cancer therapy.The article "MET signalling: principles and functions in development, organ regeneration and cancer" by Livio Trusolino, Andrea Bertotti, and Paolo M. Comoglio provides a comprehensive overview of the MET tyrosine kinase receptor and its roles in various biological processes. MET, also known as the HGF receptor, plays a crucial role in tissue remodelling, developmental morphogenesis, wound repair, organ homeostasis, and cancer metastasis. The versatility of MET-mediated responses is supported by qualitative and quantitative signal modulation, including the engagement of specific signal transducers and subcellular compartmentalization of signaling pathways. The authors discuss the molecular mechanisms underlying MET signaling, highlighting the importance of MET's interaction with various adaptor proteins and signal modifiers. They also explore how MET signaling influences different organismal functions in normal physiology and disease, emphasizing the need for a reconceptualization of these processes. The article further examines the causative relationships between individual signaling inputs and specific biological outputs in MET-driven processes, and provides insights into the medical implications of novel therapies that either promote or neutralize MET activity. In the context of embryonic development, MET and HGF are essential for the growth and survival of hepatocytes and placental trophoblast cells, as well as for the proliferation and motility of muscle progenitors. In organ regeneration, MET is crucial for liver and kidney regeneration, wound healing, and the regulation of fibrotic responses. In cancer, MET activation exacerbates the intrinsic malignant properties of transformed cells by conveying proliferative, anti-apoptotic, and pro-migratory signals. The article also discusses the potential therapeutic strategies based on targeting MET signaling in both regenerative medicine and cancer therapy.