MICADO, the Multi-AO Imaging Camera for Deep Observations, is designed for the E-ELT (European Extremely Large Telescope) and is optimized for use with the multi-conjugate adaptive optics (MCAO) system MAORY. It provides diffraction-limited imaging over a wide field of view (∼1 arcmin) and can also operate with a simpler AO module for initial operations. The instrument is compact and supported under the AO systems, allowing it to rotate in a gravity-invariant orientation. MICADO features two arms: a primary arm with a high-throughput imaging camera and an auxiliary arm for increased flexibility, including a finer pixel scale and long-slit spectroscopy. Key capabilities include high sensitivity and resolution, precision astrometry, and high-throughput spectroscopy. The design is simple, robust, and minimizes risks, with a focus on minimizing cable lengths and maintaining optical alignment during cool-down. The instrument is cooled by continuous flow liquid nitrogen to avoid vibrations affecting AO performance. The data processing system, Astro-WISE, supports automated and manual data reduction, with an estimated data rate of up to 6 Terabytes per night. The SCAO module, SAMI, is designed for initial operations and can be reused with other AO systems. Performance estimates show excellent sensitivity and resolution, with potential future developments including advanced filters, a dual imager, and high-time-resolution astronomy capabilities.MICADO, the Multi-AO Imaging Camera for Deep Observations, is designed for the E-ELT (European Extremely Large Telescope) and is optimized for use with the multi-conjugate adaptive optics (MCAO) system MAORY. It provides diffraction-limited imaging over a wide field of view (∼1 arcmin) and can also operate with a simpler AO module for initial operations. The instrument is compact and supported under the AO systems, allowing it to rotate in a gravity-invariant orientation. MICADO features two arms: a primary arm with a high-throughput imaging camera and an auxiliary arm for increased flexibility, including a finer pixel scale and long-slit spectroscopy. Key capabilities include high sensitivity and resolution, precision astrometry, and high-throughput spectroscopy. The design is simple, robust, and minimizes risks, with a focus on minimizing cable lengths and maintaining optical alignment during cool-down. The instrument is cooled by continuous flow liquid nitrogen to avoid vibrations affecting AO performance. The data processing system, Astro-WISE, supports automated and manual data reduction, with an estimated data rate of up to 6 Terabytes per night. The SCAO module, SAMI, is designed for initial operations and can be reused with other AO systems. Performance estimates show excellent sensitivity and resolution, with potential future developments including advanced filters, a dual imager, and high-time-resolution astronomy capabilities.