MXenes, a family of 2D nanomaterials, have gained significant attention due to their high electrical conductivity, processability, mechanical robustness, and chemical tunability. Flexible sensors based on MXene-polymer composites are highly promising for next-generation wearable electronics used in human-machine interfaces. This review covers the fabrication of MXene-based polymeric nanocomposites, their structure-property relationships, and applications in flexible sensor technology. The discussion extends beyond sensor design and mechanisms to include future perspectives and market trends. The article aims to strengthen the bond between flexible matrices and MXenes, promoting the rapid advancement of flexible MXene-sensors for wearable technologies. Key aspects include the fabrication strategies, properties, microstructure, and morphology of MXene/polymer nanocomposites, as well as their structural and mechanical characteristics. MXenes enhance the electrical conductivity, thermal stability, and mechanical properties of polymer composites, making them suitable for various applications such as health monitoring, sports fitness, and clinical diagnosis. The review also highlights the challenges and future possibilities in the field, emphasizing the potential of MXene-based composites in stretchable electronics and wearable devices.MXenes, a family of 2D nanomaterials, have gained significant attention due to their high electrical conductivity, processability, mechanical robustness, and chemical tunability. Flexible sensors based on MXene-polymer composites are highly promising for next-generation wearable electronics used in human-machine interfaces. This review covers the fabrication of MXene-based polymeric nanocomposites, their structure-property relationships, and applications in flexible sensor technology. The discussion extends beyond sensor design and mechanisms to include future perspectives and market trends. The article aims to strengthen the bond between flexible matrices and MXenes, promoting the rapid advancement of flexible MXene-sensors for wearable technologies. Key aspects include the fabrication strategies, properties, microstructure, and morphology of MXene/polymer nanocomposites, as well as their structural and mechanical characteristics. MXenes enhance the electrical conductivity, thermal stability, and mechanical properties of polymer composites, making them suitable for various applications such as health monitoring, sports fitness, and clinical diagnosis. The review also highlights the challenges and future possibilities in the field, emphasizing the potential of MXene-based composites in stretchable electronics and wearable devices.