This review discusses the design, properties, and applications of MXene-based elastomer mimetic stretchable sensors. MXenes, a family of 2D nanomaterials, are highly conductive, processable, and mechanically robust, making them ideal for flexible sensors. The article emphasizes the importance of integrating MXenes with flexible matrices to enhance sensor performance for wearable technologies. It covers the fabrication of MXene-polymer composites, their structure-property relationships, and applications in flexible sensors. The review also discusses the challenges and future perspectives of MXene-based sensors, highlighting their potential in wearable electronics, health monitoring, and other fields. The article highlights the benefits of MXene-polymer composites, including improved mechanical properties, electrical conductivity, and stability. It also discusses the synthesis of MXene-based composites, their properties, and applications in various fields such as energy storage, sensing, and biomedical applications. The review provides an overview of the latest advancements in flexible MXene-based composites for stretchable sensors, focusing on fabrication strategies, working mechanisms, and performance. It also discusses the current challenges and future possibilities of MXene-based sensors. The article concludes with a discussion on the microstructure and morphology of MXene-polymer composites, their structure-property relationships, and their potential applications in stretchable sensors. The review emphasizes the importance of MXene-polymer composites in the development of flexible and stretchable sensors for wearable technologies.This review discusses the design, properties, and applications of MXene-based elastomer mimetic stretchable sensors. MXenes, a family of 2D nanomaterials, are highly conductive, processable, and mechanically robust, making them ideal for flexible sensors. The article emphasizes the importance of integrating MXenes with flexible matrices to enhance sensor performance for wearable technologies. It covers the fabrication of MXene-polymer composites, their structure-property relationships, and applications in flexible sensors. The review also discusses the challenges and future perspectives of MXene-based sensors, highlighting their potential in wearable electronics, health monitoring, and other fields. The article highlights the benefits of MXene-polymer composites, including improved mechanical properties, electrical conductivity, and stability. It also discusses the synthesis of MXene-based composites, their properties, and applications in various fields such as energy storage, sensing, and biomedical applications. The review provides an overview of the latest advancements in flexible MXene-based composites for stretchable sensors, focusing on fabrication strategies, working mechanisms, and performance. It also discusses the current challenges and future possibilities of MXene-based sensors. The article concludes with a discussion on the microstructure and morphology of MXene-polymer composites, their structure-property relationships, and their potential applications in stretchable sensors. The review emphasizes the importance of MXene-polymer composites in the development of flexible and stretchable sensors for wearable technologies.