This review discusses the application of MXene-based flexible electronic materials in the detection and treatment of wound infections. Wound infections are a significant global health issue, causing severe physical and mental health problems and high medical costs. Traditional treatments like surgical debridement and antibiotics are often painful and may lead to recurring infections. Therefore, there is a pressing need for non-antibiotic treatment methods. Flexible wound dressings with physiological signal detection, pathogen inactivation, and wound-healing promotion have shown great potential in treating infected wounds. MXene-based flexible materials, with their unique electroactive, mechanical, photophysical, and biological properties, offer broad application prospects in healthcare. Wound infections are caused by bacteria that form biofilms, making them difficult to treat. The skin's role in preventing bacterial invasion is crucial, but once disrupted, bacteria can proliferate and form biofilms. These biofilms hinder the effectiveness of antibacterial agents, leading to persistent infections. The review highlights the challenges in managing infected wounds and the potential of MXene-based materials in this context. MXene-based flexible materials can detect wound infection markers such as pH, temperature, H2O2, O2-, uric acid, and bacterial virulence factors. These materials can also treat infections through photothermal therapy, antibacterial effects, and wound healing promotion. For example, Ti3C2Tx-based sensors can monitor pH changes, while Cu NPs@Cu-MOF/Ti3C2Tx/SPE can detect H2O2. Flexible sensors can also detect O2- and uric acid, providing real-time data for personalized treatment. The review also discusses the development of multifunctional sensors that can simultaneously detect multiple parameters, enhancing the accuracy of infection detection. Additionally, MXene-based materials are being used in photothermal therapy to kill bacteria and promote wound healing. These materials can be combined with other treatments to enhance their effectiveness and reduce damage to healthy tissue. The review concludes that MXene-based flexible materials offer a promising solution for the detection and treatment of wound infections, with potential for future advancements in flexible electronics and wound care.This review discusses the application of MXene-based flexible electronic materials in the detection and treatment of wound infections. Wound infections are a significant global health issue, causing severe physical and mental health problems and high medical costs. Traditional treatments like surgical debridement and antibiotics are often painful and may lead to recurring infections. Therefore, there is a pressing need for non-antibiotic treatment methods. Flexible wound dressings with physiological signal detection, pathogen inactivation, and wound-healing promotion have shown great potential in treating infected wounds. MXene-based flexible materials, with their unique electroactive, mechanical, photophysical, and biological properties, offer broad application prospects in healthcare. Wound infections are caused by bacteria that form biofilms, making them difficult to treat. The skin's role in preventing bacterial invasion is crucial, but once disrupted, bacteria can proliferate and form biofilms. These biofilms hinder the effectiveness of antibacterial agents, leading to persistent infections. The review highlights the challenges in managing infected wounds and the potential of MXene-based materials in this context. MXene-based flexible materials can detect wound infection markers such as pH, temperature, H2O2, O2-, uric acid, and bacterial virulence factors. These materials can also treat infections through photothermal therapy, antibacterial effects, and wound healing promotion. For example, Ti3C2Tx-based sensors can monitor pH changes, while Cu NPs@Cu-MOF/Ti3C2Tx/SPE can detect H2O2. Flexible sensors can also detect O2- and uric acid, providing real-time data for personalized treatment. The review also discusses the development of multifunctional sensors that can simultaneously detect multiple parameters, enhancing the accuracy of infection detection. Additionally, MXene-based materials are being used in photothermal therapy to kill bacteria and promote wound healing. These materials can be combined with other treatments to enhance their effectiveness and reduce damage to healthy tissue. The review concludes that MXene-based flexible materials offer a promising solution for the detection and treatment of wound infections, with potential for future advancements in flexible electronics and wound care.