MXene-based flexible electronic materials show great potential for wound infection detection and treatment. Wound infections are a global health issue with significant physical, mental, and economic impacts. Traditional treatments like surgical debridement and antibiotics often cause more pain and risk recurrence. Flexible wound dressings with physiological signal detection, pathogen inactivation, and wound-healing promotion are promising alternatives. MXene-based materials, with their electroactive, mechanical, photophysical, and biological properties, are particularly suitable for this application. Wound infections are caused by bacteria that form biofilms, making them difficult to treat. Current treatments are limited by their inability to detect infection status and provide real-time monitoring. MXene-based flexible materials offer advantages such as high electrical conductivity, photothermal conversion ability, and biocompatibility, enabling photothermal therapy and physical barrier protection. They also help reconstruct the endogenous electric field of wounds, promoting healing. MXene-based flexible materials can detect various wound infection markers, including pH, temperature, enzymes, toxins, and oxidative stress. They can also treat infections through photothermal therapy, bacterial removal, and wound healing. Recent studies have developed MXene-based sensors for detecting pH, H2O2, superoxide anion, uric acid, and bacterial virulence factors. These sensors use MXene's unique properties to detect biomarkers and provide real-time monitoring. In addition, MXene-based materials can be used for photothermal-mediated antimicrobial therapy, which effectively eradicates pathogens without inducing resistance. They can also be combined with other treatments, such as silver-based antibacterial therapy, to enhance effectiveness. MXene-based flexible materials can accelerate wound healing through drug delivery, electrical stimulation, and motion detection. They can also be used as smart dressings that monitor wound status and provide real-time feedback. Overall, MXene-based flexible materials offer a promising solution for wound infection detection and treatment, with the potential to improve patient outcomes and reduce healthcare costs. Further research is needed to optimize these materials for clinical applications.MXene-based flexible electronic materials show great potential for wound infection detection and treatment. Wound infections are a global health issue with significant physical, mental, and economic impacts. Traditional treatments like surgical debridement and antibiotics often cause more pain and risk recurrence. Flexible wound dressings with physiological signal detection, pathogen inactivation, and wound-healing promotion are promising alternatives. MXene-based materials, with their electroactive, mechanical, photophysical, and biological properties, are particularly suitable for this application. Wound infections are caused by bacteria that form biofilms, making them difficult to treat. Current treatments are limited by their inability to detect infection status and provide real-time monitoring. MXene-based flexible materials offer advantages such as high electrical conductivity, photothermal conversion ability, and biocompatibility, enabling photothermal therapy and physical barrier protection. They also help reconstruct the endogenous electric field of wounds, promoting healing. MXene-based flexible materials can detect various wound infection markers, including pH, temperature, enzymes, toxins, and oxidative stress. They can also treat infections through photothermal therapy, bacterial removal, and wound healing. Recent studies have developed MXene-based sensors for detecting pH, H2O2, superoxide anion, uric acid, and bacterial virulence factors. These sensors use MXene's unique properties to detect biomarkers and provide real-time monitoring. In addition, MXene-based materials can be used for photothermal-mediated antimicrobial therapy, which effectively eradicates pathogens without inducing resistance. They can also be combined with other treatments, such as silver-based antibacterial therapy, to enhance effectiveness. MXene-based flexible materials can accelerate wound healing through drug delivery, electrical stimulation, and motion detection. They can also be used as smart dressings that monitor wound status and provide real-time feedback. Overall, MXene-based flexible materials offer a promising solution for wound infection detection and treatment, with the potential to improve patient outcomes and reduce healthcare costs. Further research is needed to optimize these materials for clinical applications.