The study investigates the role of the Arabidopsis thaliana basic helix-loop-helix Leu zipper transcription factor MYC2 in modulating jasmonate (JA)-dependent functions. Through genome-wide transcriptional profiling and functional analyses, the researchers found that MYC2 negatively regulates tryptophan (Trp) and Trp-derived secondary metabolism, such as indole glucosinolate (IG) biosynthesis, during JA signaling. MYC2 also positively regulates JA-mediated resistance to insect pests and tolerance to oxidative stress, possibly by enhancing ascorbate redox cycling and flavonoid biosynthesis. The study reveals that MYC2 modulates JA responses by differentially regulating a subset of transcription factors (TFs) with activating or repressing roles in JA signaling. Additionally, MYC2 negatively regulates its own expression, which may be a mechanism for fine-tuning JA signaling. These findings provide new insights into the function of MYC2 and the transcriptional coordination of the JA signaling pathway.The study investigates the role of the Arabidopsis thaliana basic helix-loop-helix Leu zipper transcription factor MYC2 in modulating jasmonate (JA)-dependent functions. Through genome-wide transcriptional profiling and functional analyses, the researchers found that MYC2 negatively regulates tryptophan (Trp) and Trp-derived secondary metabolism, such as indole glucosinolate (IG) biosynthesis, during JA signaling. MYC2 also positively regulates JA-mediated resistance to insect pests and tolerance to oxidative stress, possibly by enhancing ascorbate redox cycling and flavonoid biosynthesis. The study reveals that MYC2 modulates JA responses by differentially regulating a subset of transcription factors (TFs) with activating or repressing roles in JA signaling. Additionally, MYC2 negatively regulates its own expression, which may be a mechanism for fine-tuning JA signaling. These findings provide new insights into the function of MYC2 and the transcriptional coordination of the JA signaling pathway.