The article provides an overview of the recent developments in *Phenix*, a comprehensive software package for determining macromolecular structures using X-ray, neutron, and electron diffraction, as well as electron cryo-microscopy (cryo-EM). The workflow for structure determination is similar across these techniques, but each method has unique properties that require tailored tools. *Phenix* emphasizes automation to minimize repetitive tasks and provides a user-friendly interface. The article covers the steps in the structure-solution process, including data-quality assessment, map optimization, model building, and refinement. It also discusses the validation of models to ensure their quality and accuracy. Recent additions to *Phenix* include tools for cryo-EM map optimization, automated model building, and ensemble refinement. The software is designed to handle various experimental data types and offers a range of tools for different stages of the structure-determination process.The article provides an overview of the recent developments in *Phenix*, a comprehensive software package for determining macromolecular structures using X-ray, neutron, and electron diffraction, as well as electron cryo-microscopy (cryo-EM). The workflow for structure determination is similar across these techniques, but each method has unique properties that require tailored tools. *Phenix* emphasizes automation to minimize repetitive tasks and provides a user-friendly interface. The article covers the steps in the structure-solution process, including data-quality assessment, map optimization, model building, and refinement. It also discusses the validation of models to ensure their quality and accuracy. Recent additions to *Phenix* include tools for cryo-EM map optimization, automated model building, and ensemble refinement. The software is designed to handle various experimental data types and offers a range of tools for different stages of the structure-determination process.