The article reviews the role of macrophage cytokines in immunity and infectious diseases. Macrophages, key components of the innate immune system, play a crucial role in phagocytosis, inflammation, and antigen presentation. Cytokines, small soluble proteins, mediate communication between immune and non-immune cells, influencing macrophage function. The review discusses the functions of proinflammatory cytokines (TNF, IL-1, IL-6, IL-8, IL-12) and anti-inflammatory cytokines (IL-10, TGF-β) secreted by macrophages, their release mechanisms, and the impact of cytokine deregulation on disease states. It also explores how pathogens, such as *Mycobacterium ulcerans* and *Leishmania*, disrupt cytokine secretion to aid their survival and dissemination. The article highlights the importance of cytokine regulation in both health and disease, providing insights into potential therapeutic targets.The article reviews the role of macrophage cytokines in immunity and infectious diseases. Macrophages, key components of the innate immune system, play a crucial role in phagocytosis, inflammation, and antigen presentation. Cytokines, small soluble proteins, mediate communication between immune and non-immune cells, influencing macrophage function. The review discusses the functions of proinflammatory cytokines (TNF, IL-1, IL-6, IL-8, IL-12) and anti-inflammatory cytokines (IL-10, TGF-β) secreted by macrophages, their release mechanisms, and the impact of cytokine deregulation on disease states. It also explores how pathogens, such as *Mycobacterium ulcerans* and *Leishmania*, disrupt cytokine secretion to aid their survival and dissemination. The article highlights the importance of cytokine regulation in both health and disease, providing insights into potential therapeutic targets.