A prospective observational study evaluated the safety and efficacy of the Magnesium–Ibogaine: the Stanford Traumatic Injury to the CNS protocol (MISTIC) in 30 male veterans with traumatic brain injuries (TBIs) primarily from mild TBI and repeated blast/combat exposures. The study assessed changes in the World Health Organization Disability Assessment Schedule 2.0 (WHODAS-2.0) from baseline to immediately and 1 month after treatment. MISTIC resulted in significant improvements in functioning, PTSD, depression, and anxiety at 1 month post-treatment. No unexpected or serious adverse events were reported. The study highlights the potential of MISTIC as a treatment for veterans with TBI-related psychiatric symptoms, including suicidality. The findings suggest that MISTIC may be effective even when administered years after injury. However, the study was not randomized, and further research is needed to confirm these results. The study also notes that ibogaine, when combined with magnesium, may offer cardioprotection and improved safety. The results indicate that MISTIC could be a promising therapeutic option for veterans with TBI and related psychiatric symptoms.A prospective observational study evaluated the safety and efficacy of the Magnesium–Ibogaine: the Stanford Traumatic Injury to the CNS protocol (MISTIC) in 30 male veterans with traumatic brain injuries (TBIs) primarily from mild TBI and repeated blast/combat exposures. The study assessed changes in the World Health Organization Disability Assessment Schedule 2.0 (WHODAS-2.0) from baseline to immediately and 1 month after treatment. MISTIC resulted in significant improvements in functioning, PTSD, depression, and anxiety at 1 month post-treatment. No unexpected or serious adverse events were reported. The study highlights the potential of MISTIC as a treatment for veterans with TBI-related psychiatric symptoms, including suicidality. The findings suggest that MISTIC may be effective even when administered years after injury. However, the study was not randomized, and further research is needed to confirm these results. The study also notes that ibogaine, when combined with magnesium, may offer cardioprotection and improved safety. The results indicate that MISTIC could be a promising therapeutic option for veterans with TBI and related psychiatric symptoms.