Magnesium (Mg²⁺) promotes vascularization and osseointegration in diabetic states. This study demonstrates that Mg²⁺ enhances angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism. Diabetic mice exhibited impaired alveolar bone healing with reduced angiogenesis. Mg-coated implants improved vascularization and osseointegration in diabetic conditions. Mechanistically, Mg²⁺ upregulates sestrin 2 (SESN2), which promotes degradation of Kelch-like ECH-associated protein 1 (Keap1) and nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2), reducing oxidative stress in endothelial cells under hyperglycemia. Mg²⁺ also enhances osteoblast differentiation and proliferation, improving bone regeneration. The study shows that Mg²⁺ mitigates endothelial dysfunction and oxidative stress, promoting vascularization and osseointegration in diabetic states. Mg-coated implants were synthesized via hydrothermal methods and showed improved osseointegration compared to titanium implants. The study highlights the potential of Mg²⁺ in improving implant success in diabetic patients.Magnesium (Mg²⁺) promotes vascularization and osseointegration in diabetic states. This study demonstrates that Mg²⁺ enhances angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism. Diabetic mice exhibited impaired alveolar bone healing with reduced angiogenesis. Mg-coated implants improved vascularization and osseointegration in diabetic conditions. Mechanistically, Mg²⁺ upregulates sestrin 2 (SESN2), which promotes degradation of Kelch-like ECH-associated protein 1 (Keap1) and nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2), reducing oxidative stress in endothelial cells under hyperglycemia. Mg²⁺ also enhances osteoblast differentiation and proliferation, improving bone regeneration. The study shows that Mg²⁺ mitigates endothelial dysfunction and oxidative stress, promoting vascularization and osseointegration in diabetic states. Mg-coated implants were synthesized via hydrothermal methods and showed improved osseointegration compared to titanium implants. The study highlights the potential of Mg²⁺ in improving implant success in diabetic patients.