This review discusses the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications in nanomedicine and regenerative medicine. mHA nanoparticles have gained significant interest due to their biocompatibility, bioactivity, and unique physicochemical features, enabling on-demand activation and control. The review highlights various synthetic methods for producing magnetic apatite-based materials, including iron-doped HA nanoparticles with intrinsic magnetic properties and composite/hybrid compounds between HA and superparamagnetic metal oxide nanoparticles. It discusses the application of mHA nanomaterials in bone regeneration and nanomedicine, and explores novel perspectives on improving nanocarriers with homogeneous structures for multifunctional biological applications. The review also covers different synthesis methods for mHA, including chemical precipitation, mechanochemical, emulsion, hydrothermal, template, sol-gel, and synergistic synthesis methods. These methods are discussed in detail, highlighting their advantages and challenges in producing mHA nanoparticles with desired properties for biomedical applications. The review emphasizes the importance of controlling the synthesis conditions to achieve homogeneous and biocompatible mHA nanoparticles with enhanced magnetic and biological properties for use in targeted drug delivery, cell stimulation, antimicrobial activity, and controlled drug release.This review discusses the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications in nanomedicine and regenerative medicine. mHA nanoparticles have gained significant interest due to their biocompatibility, bioactivity, and unique physicochemical features, enabling on-demand activation and control. The review highlights various synthetic methods for producing magnetic apatite-based materials, including iron-doped HA nanoparticles with intrinsic magnetic properties and composite/hybrid compounds between HA and superparamagnetic metal oxide nanoparticles. It discusses the application of mHA nanomaterials in bone regeneration and nanomedicine, and explores novel perspectives on improving nanocarriers with homogeneous structures for multifunctional biological applications. The review also covers different synthesis methods for mHA, including chemical precipitation, mechanochemical, emulsion, hydrothermal, template, sol-gel, and synergistic synthesis methods. These methods are discussed in detail, highlighting their advantages and challenges in producing mHA nanoparticles with desired properties for biomedical applications. The review emphasizes the importance of controlling the synthesis conditions to achieve homogeneous and biocompatible mHA nanoparticles with enhanced magnetic and biological properties for use in targeted drug delivery, cell stimulation, antimicrobial activity, and controlled drug release.