This review discusses the development of nanopesticides with minimizing carriers (NMC), which are designed to reduce the use of nanomaterials in pesticide delivery systems. NMC systems are created through prodrug design and molecular self-assembly, offering a more efficient and safer alternative to traditional nanopesticides that use non-therapeutic nanomaterials as carriers (NNC). The review highlights the advantages of NMC, including high loading capacity, reduced toxicity, and enhanced functionality. It also addresses the challenges in the preparation, performance, and production of NMC systems, emphasizing the need for further research to optimize their development. The study compares NMC and NNC in terms of their properties, toxicity, and environmental impact, suggesting that NMC could play a key role in the future of sustainable and efficient nanopesticides. The review also discusses the potential of molecular self-assembly and other strategies in the development of NMC, as well as the importance of cost-effective and scalable production methods. Overall, the review advocates for the continued exploration of NMC as a promising approach to address the environmental and safety concerns associated with traditional nanopesticides.This review discusses the development of nanopesticides with minimizing carriers (NMC), which are designed to reduce the use of nanomaterials in pesticide delivery systems. NMC systems are created through prodrug design and molecular self-assembly, offering a more efficient and safer alternative to traditional nanopesticides that use non-therapeutic nanomaterials as carriers (NNC). The review highlights the advantages of NMC, including high loading capacity, reduced toxicity, and enhanced functionality. It also addresses the challenges in the preparation, performance, and production of NMC systems, emphasizing the need for further research to optimize their development. The study compares NMC and NNC in terms of their properties, toxicity, and environmental impact, suggesting that NMC could play a key role in the future of sustainable and efficient nanopesticides. The review also discusses the potential of molecular self-assembly and other strategies in the development of NMC, as well as the importance of cost-effective and scalable production methods. Overall, the review advocates for the continued exploration of NMC as a promising approach to address the environmental and safety concerns associated with traditional nanopesticides.