UvA-DARE is a digital academic repository. The article "Mammalian ABC transporters in health and disease" by Borst and Oude Elferink reviews the functions of mammalian ABC transporters, emphasizing biochemical mechanisms and genetic defects. ABC transporters are large membrane proteins that transport various compounds against concentration gradients using ATP. The human genome contains 48 ABC genes, with 16 having known functions and 14 associated with diseases. These transporters play key roles in lipid transport, bile salt transport, and drug resistance. The review discusses three main topics: (1) ABC transporters involved in drug transport, (2) secretory epithelia using ABC transporters to excrete substances, and (3) ABC transporters in lipid transport. The article also covers the regulation of ABC transporter expression and their roles in disease. Key ABC transporters discussed include P-glycoprotein, BCRP, and MRPs. The review highlights the importance of ABC transporters in human physiology, toxicology, pharmacology, and disease. It also discusses the genetic defects associated with ABC transporters and their impact on drug disposition. The article concludes with the significance of ABC transporters in drug resistance and their potential as therapeutic targets.UvA-DARE is a digital academic repository. The article "Mammalian ABC transporters in health and disease" by Borst and Oude Elferink reviews the functions of mammalian ABC transporters, emphasizing biochemical mechanisms and genetic defects. ABC transporters are large membrane proteins that transport various compounds against concentration gradients using ATP. The human genome contains 48 ABC genes, with 16 having known functions and 14 associated with diseases. These transporters play key roles in lipid transport, bile salt transport, and drug resistance. The review discusses three main topics: (1) ABC transporters involved in drug transport, (2) secretory epithelia using ABC transporters to excrete substances, and (3) ABC transporters in lipid transport. The article also covers the regulation of ABC transporter expression and their roles in disease. Key ABC transporters discussed include P-glycoprotein, BCRP, and MRPs. The review highlights the importance of ABC transporters in human physiology, toxicology, pharmacology, and disease. It also discusses the genetic defects associated with ABC transporters and their impact on drug disposition. The article concludes with the significance of ABC transporters in drug resistance and their potential as therapeutic targets.