The panel discussion on the management of solitary thyroid nodules focuses on the conventional approach of surgical intervention and explores alternative methods. Dr. Virginia Kneeland Frantz, a surgical pathologist, emphasizes the challenges in differentiating benign from malignant nodules, noting that many solitary nodules are adenomas, and that the prognosis can be difficult to predict. Dr. George Crile, Jr., a surgeon, advocates for a physiological approach, suggesting that thyroid nodules are endocrine-dependent and can be managed by suppressing thyroid-stimulating hormone (TSH) with thyroid hormone. He presents clinical examples of successful regression of thyroid tumors under thyroid administration. Dr. Sidney C. Werner, an internist, discusses the importance of proper physical examination and laboratory tests to differentiate thyroid nodules, and suggests that thyroid hormone administration can be a useful initial treatment for some nodules. Dr. Rulon W. Rawson, a researcher, reviews experimental studies on thyroid cancer, highlighting the complex relationship between TSH and thyroid cancer growth. He suggests that some thyroid cancers may be influenced by physiological stimuli and that thyroid hormone administration could potentially control tumor growth. The discussion highlights the ongoing debate between surgical intervention and alternative treatments, with each panelist offering insights into the complexities of managing thyroid nodules.The panel discussion on the management of solitary thyroid nodules focuses on the conventional approach of surgical intervention and explores alternative methods. Dr. Virginia Kneeland Frantz, a surgical pathologist, emphasizes the challenges in differentiating benign from malignant nodules, noting that many solitary nodules are adenomas, and that the prognosis can be difficult to predict. Dr. George Crile, Jr., a surgeon, advocates for a physiological approach, suggesting that thyroid nodules are endocrine-dependent and can be managed by suppressing thyroid-stimulating hormone (TSH) with thyroid hormone. He presents clinical examples of successful regression of thyroid tumors under thyroid administration. Dr. Sidney C. Werner, an internist, discusses the importance of proper physical examination and laboratory tests to differentiate thyroid nodules, and suggests that thyroid hormone administration can be a useful initial treatment for some nodules. Dr. Rulon W. Rawson, a researcher, reviews experimental studies on thyroid cancer, highlighting the complex relationship between TSH and thyroid cancer growth. He suggests that some thyroid cancers may be influenced by physiological stimuli and that thyroid hormone administration could potentially control tumor growth. The discussion highlights the ongoing debate between surgical intervention and alternative treatments, with each panelist offering insights into the complexities of managing thyroid nodules.