The study by Hagmann et al. (2008) used diffusion spectrum imaging to map the structural connections within and across the human cerebral cortex, revealing a dense network of cortico-cortical axonal pathways. The analysis of these large-scale structural brain networks identified a structural core within the posterior medial and parietal cortex, as well as several distinct temporal and frontal modules. Key features of the structural core include high degree, strength, and betweenness centrality, suggesting that these regions serve as connector hubs linking major structural modules. The core contains brain regions that form part of the default network, which is highly activated at rest. The study also found a significant correspondence between structural connectivity and resting-state functional connectivity, indicating that the structural core plays a crucial role in integrating information across functionally segregated brain regions. The findings highlight the importance of the structural core in shaping large-scale brain dynamics and suggest that it may be a critical structural basis for the default network's activity.The study by Hagmann et al. (2008) used diffusion spectrum imaging to map the structural connections within and across the human cerebral cortex, revealing a dense network of cortico-cortical axonal pathways. The analysis of these large-scale structural brain networks identified a structural core within the posterior medial and parietal cortex, as well as several distinct temporal and frontal modules. Key features of the structural core include high degree, strength, and betweenness centrality, suggesting that these regions serve as connector hubs linking major structural modules. The core contains brain regions that form part of the default network, which is highly activated at rest. The study also found a significant correspondence between structural connectivity and resting-state functional connectivity, indicating that the structural core plays a crucial role in integrating information across functionally segregated brain regions. The findings highlight the importance of the structural core in shaping large-scale brain dynamics and suggest that it may be a critical structural basis for the default network's activity.