This review covers the literature published in 2022 on marine natural products (MNPs), focusing on new compounds and their biological activities, source organisms, and country of origin. It highlights 1,417 new compounds from 384 papers, a decrease from the 1,425 new compounds reported in 2021. The review also includes known MNPs reported from marine sources for the first time and those with revised structures. A new artifact category is introduced, including three compounds. The review discusses the diversity of NP structure classes in relation to biota sources and biomes. The introduction provides background on the annual review of marine natural products, noting its 40th anniversary. It emphasizes the importance of machine learning and density functional theory in structure assignment and highlights the use of metabolomic-guided strategies for strain prioritization and genome mining. The review is divided into sections covering marine microorganisms and phytoplankton, cyanobacteria, and marine-sourced fungi (excluding mangroves). Each section details the sources, structures, and biological activities of new MNPs, with a focus on unique ecological niches such as deep-sea environments and the gut microbiota of Antarctic emperor penguins. The review also includes total syntheses, structural revisions, and reviews on the biosynthesis and potential of marine MNPs. Overall, the 2022 literature highlights the continued exploration of marine environments for novel MNPs, with a particular emphasis on deep-sea and invertebrate sources. The review underscores the importance of genome- and metabolomics-guided studies in discovering new compounds and the role of machine learning in structure assignment.This review covers the literature published in 2022 on marine natural products (MNPs), focusing on new compounds and their biological activities, source organisms, and country of origin. It highlights 1,417 new compounds from 384 papers, a decrease from the 1,425 new compounds reported in 2021. The review also includes known MNPs reported from marine sources for the first time and those with revised structures. A new artifact category is introduced, including three compounds. The review discusses the diversity of NP structure classes in relation to biota sources and biomes. The introduction provides background on the annual review of marine natural products, noting its 40th anniversary. It emphasizes the importance of machine learning and density functional theory in structure assignment and highlights the use of metabolomic-guided strategies for strain prioritization and genome mining. The review is divided into sections covering marine microorganisms and phytoplankton, cyanobacteria, and marine-sourced fungi (excluding mangroves). Each section details the sources, structures, and biological activities of new MNPs, with a focus on unique ecological niches such as deep-sea environments and the gut microbiota of Antarctic emperor penguins. The review also includes total syntheses, structural revisions, and reviews on the biosynthesis and potential of marine MNPs. Overall, the 2022 literature highlights the continued exploration of marine environments for novel MNPs, with a particular emphasis on deep-sea and invertebrate sources. The review underscores the importance of genome- and metabolomics-guided studies in discovering new compounds and the role of machine learning in structure assignment.