This review summarizes the marine natural products (MNPs) reported in 2022, highlighting 1417 new compounds from 384 papers. The review covers compounds isolated from marine microorganisms, phytoplankton, green, brown, and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, and other intertidal plants. The emphasis is on new compounds, their biological activities, source organisms, and country of origin. The review includes pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to structural revisions or stereochemical changes. It also discusses the diversity of NP structure classes in relation to biota sources and biomes. The review highlights the significant contributions of various marine organisms, including bacteria, cyanobacteria, and fungi. For example, Actinobacteria were the most common source of bacterial compounds in 2022, with 182 new NPs reported. Several new compounds were isolated from marine-derived bacteria, including new angucyclinones, chromones, and other bioactive molecules. Cyanobacteria also contributed significantly, with 30 new NP structures reported, including various peptides and polyketides. Fungi, particularly from the genus Aspergillus, were also a major source of new compounds. The review includes numerous new fungal metabolites, such as pyrrolinone-fused benzozepine alkaloids, indole alkaloids, and various other bioactive compounds. Additionally, the review discusses the biosynthesis of marine cyanobacterial NPs, including the distribution, NP chemistry, and ecology of Moorena producens. The review also highlights the use of advanced techniques such as machine learning and density functional theory to revise the stereochemistry of compounds. For example, the stereochemistry of tersone E was revised using DU8ML. The review emphasizes the importance of these techniques in accurately determining the structures of new compounds. Overall, the review provides a comprehensive overview of the marine natural products reported in 2022, highlighting the diversity of compounds, their sources, and their biological activities. It also underscores the importance of continued research in this field to discover new compounds with potential therapeutic applications.This review summarizes the marine natural products (MNPs) reported in 2022, highlighting 1417 new compounds from 384 papers. The review covers compounds isolated from marine microorganisms, phytoplankton, green, brown, and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, and other intertidal plants. The emphasis is on new compounds, their biological activities, source organisms, and country of origin. The review includes pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to structural revisions or stereochemical changes. It also discusses the diversity of NP structure classes in relation to biota sources and biomes. The review highlights the significant contributions of various marine organisms, including bacteria, cyanobacteria, and fungi. For example, Actinobacteria were the most common source of bacterial compounds in 2022, with 182 new NPs reported. Several new compounds were isolated from marine-derived bacteria, including new angucyclinones, chromones, and other bioactive molecules. Cyanobacteria also contributed significantly, with 30 new NP structures reported, including various peptides and polyketides. Fungi, particularly from the genus Aspergillus, were also a major source of new compounds. The review includes numerous new fungal metabolites, such as pyrrolinone-fused benzozepine alkaloids, indole alkaloids, and various other bioactive compounds. Additionally, the review discusses the biosynthesis of marine cyanobacterial NPs, including the distribution, NP chemistry, and ecology of Moorena producens. The review also highlights the use of advanced techniques such as machine learning and density functional theory to revise the stereochemistry of compounds. For example, the stereochemistry of tersone E was revised using DU8ML. The review emphasizes the importance of these techniques in accurately determining the structures of new compounds. Overall, the review provides a comprehensive overview of the marine natural products reported in 2022, highlighting the diversity of compounds, their sources, and their biological activities. It also underscores the importance of continued research in this field to discover new compounds with potential therapeutic applications.