The article "Meal Timing and Its Role in Obesity and Associated Diseases" explores the impact of meal timing on metabolic health and the development of obesity and related diseases. The circadian clock, which regulates physiological and behavioral rhythms, plays a crucial role in metabolic processes. Disruption of this clock, often due to modern lifestyles, increases the risk of obesity, type 2 diabetes, and cardiovascular diseases. Food intake, a key zeitgeber, is influenced by various factors such as social structures, chronotypes, and environmental conditions. The article discusses how meal timing affects peripheral clocks in metabolic tissues, leading to metabolic dysregulation. Studies in rodents and humans have shown that mistimed food intake can cause weight gain, impaired glucose tolerance, insulin resistance, and other metabolic disorders. The article also examines the mechanisms behind these effects, including hormonal changes, digestive component regulation, and microbial dynamics. Time-restricted eating (TRE) is proposed as a potential intervention to improve metabolic health by shortening the eating window. Various factors, such as sex, age, physical and mental disorders, genetic factors, meal composition, chronotype, and lifestyle, influence meal timing and metabolic outcomes. The article concludes by highlighting the need for personalized approaches to meal timing to optimize metabolic health and prevent chronic diseases.The article "Meal Timing and Its Role in Obesity and Associated Diseases" explores the impact of meal timing on metabolic health and the development of obesity and related diseases. The circadian clock, which regulates physiological and behavioral rhythms, plays a crucial role in metabolic processes. Disruption of this clock, often due to modern lifestyles, increases the risk of obesity, type 2 diabetes, and cardiovascular diseases. Food intake, a key zeitgeber, is influenced by various factors such as social structures, chronotypes, and environmental conditions. The article discusses how meal timing affects peripheral clocks in metabolic tissues, leading to metabolic dysregulation. Studies in rodents and humans have shown that mistimed food intake can cause weight gain, impaired glucose tolerance, insulin resistance, and other metabolic disorders. The article also examines the mechanisms behind these effects, including hormonal changes, digestive component regulation, and microbial dynamics. Time-restricted eating (TRE) is proposed as a potential intervention to improve metabolic health by shortening the eating window. Various factors, such as sex, age, physical and mental disorders, genetic factors, meal composition, chronotype, and lifestyle, influence meal timing and metabolic outcomes. The article concludes by highlighting the need for personalized approaches to meal timing to optimize metabolic health and prevent chronic diseases.