This study investigates the mechanical properties of bulk Sylgard 184, a commonly used polydimethylsiloxane (PDMS) elastomer, over a curing temperature range of 25 °C to 200 °C. The research aims to provide fundamental design information for microfluidic and microengineering applications. PDMS samples were fabricated according to ASTM standards for tensile and compressive testing. The results show that the Young’s modulus, ultimate tensile strength, compressive modulus, ultimate compressive strength, and hardness of Sylgard 184 vary significantly with curing temperature. Specifically, the Young’s modulus increases linearly from 1.32 MPa to 2.97 MPa, the compressive modulus decreases from 186.9 MPa to 117.8 MPa, and the hardness increases from 44 to 54 Shore A. These findings highlight the importance of considering curing temperature when designing microfluidic devices to optimize their mechanical performance.This study investigates the mechanical properties of bulk Sylgard 184, a commonly used polydimethylsiloxane (PDMS) elastomer, over a curing temperature range of 25 °C to 200 °C. The research aims to provide fundamental design information for microfluidic and microengineering applications. PDMS samples were fabricated according to ASTM standards for tensile and compressive testing. The results show that the Young’s modulus, ultimate tensile strength, compressive modulus, ultimate compressive strength, and hardness of Sylgard 184 vary significantly with curing temperature. Specifically, the Young’s modulus increases linearly from 1.32 MPa to 2.97 MPa, the compressive modulus decreases from 186.9 MPa to 117.8 MPa, and the hardness increases from 44 to 54 Shore A. These findings highlight the importance of considering curing temperature when designing microfluidic devices to optimize their mechanical performance.