The article "Mechanics, malignancy, and metastasis: The force journey of a tumor cell" by Sanjay Kumar and Valerie M. Weaver explores the critical role of mechanical changes in tumor cells and their microenvironment in the progression from benign to malignant and metastatic states. The authors highlight how alterations in cell and tissue structure, extracellular matrix (ECM) properties, and cellular mechanics contribute to tumor development. They discuss the biophysical basis of these changes, including the interplay between cell mechanics and the ECM, and review methods for measuring cellular mechanical properties both in vitro and in vivo. The article also delves into molecular mechanisms, such as Rho GTPase and focal adhesion kinase (FAK), that mediate tumor cells' response to mechanical forces. Finally, it emphasizes the importance of integrating mechanobiology with traditional cancer biology to better understand and potentially treat cancer.The article "Mechanics, malignancy, and metastasis: The force journey of a tumor cell" by Sanjay Kumar and Valerie M. Weaver explores the critical role of mechanical changes in tumor cells and their microenvironment in the progression from benign to malignant and metastatic states. The authors highlight how alterations in cell and tissue structure, extracellular matrix (ECM) properties, and cellular mechanics contribute to tumor development. They discuss the biophysical basis of these changes, including the interplay between cell mechanics and the ECM, and review methods for measuring cellular mechanical properties both in vitro and in vivo. The article also delves into molecular mechanisms, such as Rho GTPase and focal adhesion kinase (FAK), that mediate tumor cells' response to mechanical forces. Finally, it emphasizes the importance of integrating mechanobiology with traditional cancer biology to better understand and potentially treat cancer.