The article discusses the role of mechanical forces in tumor progression, focusing on how tumor cells undergo changes in their mechanical properties and the surrounding extracellular matrix (ECM) during transformation and metastasis. It highlights the importance of mechanical cues in tumor cell behavior, including cell adhesion, migration, and invasion. The text explains that tumor cells sense and respond to mechanical forces through complex mechanochemical systems, including adhesion receptors, cytoskeletal networks, and molecular motors. These systems enable cells to generate force, remodel the ECM, and coordinate with signaling pathways to control cell behavior. The article also reviews recent advances in measuring cellular mechanical properties in vitro and in vivo, such as atomic force microscopy (AFM) and subcellular laser ablation (SLA). It discusses the molecular mechanisms through which tumor cells sense and respond to mechanical forces, including Rho GTPase and focal adhesion kinase (FAK). The text emphasizes the importance of understanding the mechanical aspects of tumor growth, survival, and motility, as well as the potential for developing new cancer therapies based on this knowledge. The article concludes by highlighting the need for integrating mechanobiology with traditional cancer biology to better understand the complex interplay between mechanical forces and tumor progression.The article discusses the role of mechanical forces in tumor progression, focusing on how tumor cells undergo changes in their mechanical properties and the surrounding extracellular matrix (ECM) during transformation and metastasis. It highlights the importance of mechanical cues in tumor cell behavior, including cell adhesion, migration, and invasion. The text explains that tumor cells sense and respond to mechanical forces through complex mechanochemical systems, including adhesion receptors, cytoskeletal networks, and molecular motors. These systems enable cells to generate force, remodel the ECM, and coordinate with signaling pathways to control cell behavior. The article also reviews recent advances in measuring cellular mechanical properties in vitro and in vivo, such as atomic force microscopy (AFM) and subcellular laser ablation (SLA). It discusses the molecular mechanisms through which tumor cells sense and respond to mechanical forces, including Rho GTPase and focal adhesion kinase (FAK). The text emphasizes the importance of understanding the mechanical aspects of tumor growth, survival, and motility, as well as the potential for developing new cancer therapies based on this knowledge. The article concludes by highlighting the need for integrating mechanobiology with traditional cancer biology to better understand the complex interplay between mechanical forces and tumor progression.