The article "Mechanism of LncRNA Gm2044 in Germ Cell Development" by Qinran Zhu et al. explores the role of long non-coding RNA (lncRNA) Gm2044 in the development of germ cells in both males and females. LncRNA Gm2044 is highly expressed in specific stages of meiosis in male and female germ cells and plays a crucial role in spermatogenesis and estrogen synthesis, respectively. The authors highlight that lncRNA Gm2044 interacts with various miRNAs and transcription factors to regulate these processes. Specifically, in males, lncRNA Gm2044 interacts with UTF1 mRNA to regulate UTF1 protein expression, which is essential for germ cell meiosis. In females, lncRNA Gm2044 acts as a miR-138-5p sponge to promote estradiol synthesis by regulating *Nr5a1* and *Sirt1*. The study also discusses the potential involvement of lncRNA Gm2044 in reproductive disorders such as non-obstructive azoospermia and polycystic ovary syndrome (PCOS). The findings suggest that targeting lncRNA Gm2044 may be a promising approach for treating infertility and other reproductive disorders.The article "Mechanism of LncRNA Gm2044 in Germ Cell Development" by Qinran Zhu et al. explores the role of long non-coding RNA (lncRNA) Gm2044 in the development of germ cells in both males and females. LncRNA Gm2044 is highly expressed in specific stages of meiosis in male and female germ cells and plays a crucial role in spermatogenesis and estrogen synthesis, respectively. The authors highlight that lncRNA Gm2044 interacts with various miRNAs and transcription factors to regulate these processes. Specifically, in males, lncRNA Gm2044 interacts with UTF1 mRNA to regulate UTF1 protein expression, which is essential for germ cell meiosis. In females, lncRNA Gm2044 acts as a miR-138-5p sponge to promote estradiol synthesis by regulating *Nr5a1* and *Sirt1*. The study also discusses the potential involvement of lncRNA Gm2044 in reproductive disorders such as non-obstructive azoospermia and polycystic ovary syndrome (PCOS). The findings suggest that targeting lncRNA Gm2044 may be a promising approach for treating infertility and other reproductive disorders.