The article "Mechanoresponsive Flexible Crystals" by Zhihua Wang et al. provides a comprehensive review of the development and mechanisms of flexible crystals over the past two decades. Flexible crystals, known for their pliability, plasticity, and adaptability, have gained significant attention in various research and application fields. The main challenges in developing these crystals lie in their rational design, preparation, and performance optimization. The authors analyze the elastic standards and plastic bending mechanisms tailored to different types of flexible crystals, discussing the theoretical basis and applicability of these mechanisms. The article highlights the importance of understanding the fundamental origins of crystal flexibility to establish evaluation criteria and design principles. It discusses the compatibility between crystal elasticity and plasticity, emphasizing the potential of elastic/plastic crystals in biomedicine, flexible electronic devices, and flexible optics. The authors also present state-of-the-art experimental avenues and analysis methods for investigating molecular interactions in molecular crystals, which are crucial for future research. The review covers both plastic and elastic deformation mechanisms. Plastic deformation, where the crystal retains its shape after removal of the applied force, is often associated with anisotropic packing modes, while elastic deformation, where the crystal can recover its original shape, is characterized by isotropic packing. The article explores various models for these deformations, including the anisotropic stacking model, the slip planes model, and the "Spaghetti" model for plastic deformation, and the isotropic interlocking stacking model, the fibril lamella morphology model, and the reversible molecular rotation model for elastic deformation. The authors conclude by emphasizing the importance of understanding the mechanisms behind flexible deformation to optimize the design and manufacture of flexible crystals, and they provide insights into the future prospects of this emerging field.The article "Mechanoresponsive Flexible Crystals" by Zhihua Wang et al. provides a comprehensive review of the development and mechanisms of flexible crystals over the past two decades. Flexible crystals, known for their pliability, plasticity, and adaptability, have gained significant attention in various research and application fields. The main challenges in developing these crystals lie in their rational design, preparation, and performance optimization. The authors analyze the elastic standards and plastic bending mechanisms tailored to different types of flexible crystals, discussing the theoretical basis and applicability of these mechanisms. The article highlights the importance of understanding the fundamental origins of crystal flexibility to establish evaluation criteria and design principles. It discusses the compatibility between crystal elasticity and plasticity, emphasizing the potential of elastic/plastic crystals in biomedicine, flexible electronic devices, and flexible optics. The authors also present state-of-the-art experimental avenues and analysis methods for investigating molecular interactions in molecular crystals, which are crucial for future research. The review covers both plastic and elastic deformation mechanisms. Plastic deformation, where the crystal retains its shape after removal of the applied force, is often associated with anisotropic packing modes, while elastic deformation, where the crystal can recover its original shape, is characterized by isotropic packing. The article explores various models for these deformations, including the anisotropic stacking model, the slip planes model, and the "Spaghetti" model for plastic deformation, and the isotropic interlocking stacking model, the fibril lamella morphology model, and the reversible molecular rotation model for elastic deformation. The authors conclude by emphasizing the importance of understanding the mechanisms behind flexible deformation to optimize the design and manufacture of flexible crystals, and they provide insights into the future prospects of this emerging field.