This review discusses medical device-associated infections caused by biofilm-forming microbial pathogens and strategies to control them. Biofilms, which are complex communities of microorganisms enclosed in a self-produced extracellular matrix, are a major cause of infections linked to medical devices such as urinary catheters, intravascular catheters, and orthopedic implants. These biofilms provide a protective barrier that makes bacteria resistant to antimicrobial treatments, increasing the risk of infection. The review highlights the role of biofilms in healthcare-associated infections (HAIs), which are a significant global health issue, leading to increased mortality and morbidity. The formation of biofilms is influenced by various factors, including the type and number of cells, the physicochemical properties of the surface, and the environment in which the device is placed. The review also explores the mechanisms by which bacteria adhere to medical devices and form biofilms, as well as the challenges in controlling these biofilms. The study emphasizes the importance of developing effective strategies to prevent biofilm formation and reduce the risk of infections. These strategies include the use of antibacterial and antifouling coatings on the surfaces of biomedical devices, which can prevent microbial adhesion and biofilm formation. The review also discusses recent advancements in the development of antiadhesive or antifouling coatings on the surfaces of biomedical devices, which have shown promise in preventing biofilm-related infections. The study concludes that further research is needed to develop more effective strategies for controlling biofilm-associated infections and improving patient outcomes.This review discusses medical device-associated infections caused by biofilm-forming microbial pathogens and strategies to control them. Biofilms, which are complex communities of microorganisms enclosed in a self-produced extracellular matrix, are a major cause of infections linked to medical devices such as urinary catheters, intravascular catheters, and orthopedic implants. These biofilms provide a protective barrier that makes bacteria resistant to antimicrobial treatments, increasing the risk of infection. The review highlights the role of biofilms in healthcare-associated infections (HAIs), which are a significant global health issue, leading to increased mortality and morbidity. The formation of biofilms is influenced by various factors, including the type and number of cells, the physicochemical properties of the surface, and the environment in which the device is placed. The review also explores the mechanisms by which bacteria adhere to medical devices and form biofilms, as well as the challenges in controlling these biofilms. The study emphasizes the importance of developing effective strategies to prevent biofilm formation and reduce the risk of infections. These strategies include the use of antibacterial and antifouling coatings on the surfaces of biomedical devices, which can prevent microbial adhesion and biofilm formation. The review also discusses recent advancements in the development of antiadhesive or antifouling coatings on the surfaces of biomedical devices, which have shown promise in preventing biofilm-related infections. The study concludes that further research is needed to develop more effective strategies for controlling biofilm-associated infections and improving patient outcomes.