The article discusses the significant impact of nosocomial infections, particularly those caused by biofilm-forming microbial pathogens, on healthcare systems. Biofilms, which are complex microbial communities, are a major cause of hospital-acquired infections, including bloodstream, surgical site, skin and soft tissue, respiratory tract, and urinary tract infections. Gram-positive and Gram-negative bacteria, such as *Staphylococcus aureus*, *Escherichia coli*, *Acinetobacter baumannii*, and *Pseudomonas aeruginosa*, are the primary pathogens responsible for these infections. The formation of biofilms involves several stages, including bacterial attachment, aggregation, microcolony formation, maturation, and dispersion/detachment. Biofilms provide a protective barrier that enhances bacterial resistance to antibiotics and increases the risk of infection. The article highlights the importance of understanding the mechanisms of biofilm formation and the development of effective control strategies. Recent advancements in antibacterial coatings, including those with antibiofilm and antifouling properties, are discussed as promising solutions to combat biofilm-related infections. These coatings aim to prevent bacterial adherence, inhibit biofilm growth, and enhance the effectiveness of antimicrobial treatments. The article also emphasizes the need for further research to improve early detection and treatment of biofilm infections, as well as the development of customized coatings tailored to specific patient needs and microbial environments.The article discusses the significant impact of nosocomial infections, particularly those caused by biofilm-forming microbial pathogens, on healthcare systems. Biofilms, which are complex microbial communities, are a major cause of hospital-acquired infections, including bloodstream, surgical site, skin and soft tissue, respiratory tract, and urinary tract infections. Gram-positive and Gram-negative bacteria, such as *Staphylococcus aureus*, *Escherichia coli*, *Acinetobacter baumannii*, and *Pseudomonas aeruginosa*, are the primary pathogens responsible for these infections. The formation of biofilms involves several stages, including bacterial attachment, aggregation, microcolony formation, maturation, and dispersion/detachment. Biofilms provide a protective barrier that enhances bacterial resistance to antibiotics and increases the risk of infection. The article highlights the importance of understanding the mechanisms of biofilm formation and the development of effective control strategies. Recent advancements in antibacterial coatings, including those with antibiofilm and antifouling properties, are discussed as promising solutions to combat biofilm-related infections. These coatings aim to prevent bacterial adherence, inhibit biofilm growth, and enhance the effectiveness of antimicrobial treatments. The article also emphasizes the need for further research to improve early detection and treatment of biofilm infections, as well as the development of customized coatings tailored to specific patient needs and microbial environments.