The article by Gunther Eysenbach, titled "Medicine 2.0: Social Networking, Collaboration, Participation, Apomediation, and Openness," discusses the significant development of Web 2.0 technologies and their impact on healthcare. The emergence of Personal Health Application Platforms (PHAPs) and Personally Controlled Health Records (PCHR) platforms, such as Google Health, Microsoft HealthVault, and Dossia, has led to a shift in patient control over their medical data. These platforms enable users to manage and share their health information, fostering a new generation of health applications known as "PHR 2.0." The article highlights five key aspects of Medicine 2.0: social networking, participation, apomediation, collaboration, and openness. Social networking allows users to connect and collaborate, enabling the sharing of relevant information and improving communication. Participation emphasizes consumer involvement in healthcare, particularly through PHR 2.0. Apomediation is a term coined to describe the process of users identifying trustworthy information without relying on intermediaries. Collaboration involves connecting diverse user groups to enhance knowledge translation and decision-making. Openness promotes transparency and interoperability, allowing users to control their data and access a broader range of information. The Journal of Medical Internet Research (JMIR) has sponsored a conference and published a theme issue on Medicine 2.0 to stimulate research in these areas. The article also discusses the broader implications of Medicine 2.0, including the need for healthcare systems to move away from traditional, hierarchical structures and towards more collaborative and consumer-centric models.The article by Gunther Eysenbach, titled "Medicine 2.0: Social Networking, Collaboration, Participation, Apomediation, and Openness," discusses the significant development of Web 2.0 technologies and their impact on healthcare. The emergence of Personal Health Application Platforms (PHAPs) and Personally Controlled Health Records (PCHR) platforms, such as Google Health, Microsoft HealthVault, and Dossia, has led to a shift in patient control over their medical data. These platforms enable users to manage and share their health information, fostering a new generation of health applications known as "PHR 2.0." The article highlights five key aspects of Medicine 2.0: social networking, participation, apomediation, collaboration, and openness. Social networking allows users to connect and collaborate, enabling the sharing of relevant information and improving communication. Participation emphasizes consumer involvement in healthcare, particularly through PHR 2.0. Apomediation is a term coined to describe the process of users identifying trustworthy information without relying on intermediaries. Collaboration involves connecting diverse user groups to enhance knowledge translation and decision-making. Openness promotes transparency and interoperability, allowing users to control their data and access a broader range of information. The Journal of Medical Internet Research (JMIR) has sponsored a conference and published a theme issue on Medicine 2.0 to stimulate research in these areas. The article also discusses the broader implications of Medicine 2.0, including the need for healthcare systems to move away from traditional, hierarchical structures and towards more collaborative and consumer-centric models.