This article presents a consensus and guidelines for the diagnosis, staging, and treatment of melanoma in dogs and cats. The authors emphasize the importance of accurate diagnosis and staging to guide treatment decisions. Melanoma is a common tumor in dogs but rare in cats. It can occur in various locations, including the oral cavity, skin, digits, and eyes. The prognosis varies depending on the location and stage of the tumor. Surgical resection with wide margins is the mainstay of treatment for local control, while radiotherapy is an important adjunct in the management of oral melanomas. Adjuvant immunotherapy or chemotherapy may be offered to patients at high risk of developing distant metastasis. The article also discusses the use of biomarkers and genetic testing in the diagnosis and management of melanoma. The guidelines emphasize the importance of a multidisciplinary approach to the management of melanoma in dogs and cats.This article presents a consensus and guidelines for the diagnosis, staging, and treatment of melanoma in dogs and cats. The authors emphasize the importance of accurate diagnosis and staging to guide treatment decisions. Melanoma is a common tumor in dogs but rare in cats. It can occur in various locations, including the oral cavity, skin, digits, and eyes. The prognosis varies depending on the location and stage of the tumor. Surgical resection with wide margins is the mainstay of treatment for local control, while radiotherapy is an important adjunct in the management of oral melanomas. Adjuvant immunotherapy or chemotherapy may be offered to patients at high risk of developing distant metastasis. The article also discusses the use of biomarkers and genetic testing in the diagnosis and management of melanoma. The guidelines emphasize the importance of a multidisciplinary approach to the management of melanoma in dogs and cats.