This research explores the evolving role of Management Information Systems (MIS) in the business world, focusing on its transformation from a data processing tool to a strategic catalyst that drives business model innovation and enhances organizational interactions with customers and competitors. The study highlights how MIS can be leveraged for innovation and differentiation while addressing challenges such as data security, system integration, and employee training. Using industry surveys and in-depth interviews with practitioners, the research aims to assess how MIS supports business strategy and operational decisions, and to identify and overcome implementation challenges. The findings are expected to provide practical guidance for business leaders and IT professionals, as well as contribute to academic literature on MIS in dynamic business environments. The study reveals that MIS plays a critical role in supporting business strategy and decision-making, and contributes to innovation and differentiation in competitive environments. Key findings include differences in MIS usage, effectiveness, and challenges based on company size, industry, and user experience. Startups have lower MIS usage, while SMEs show higher effectiveness. Large companies have higher usage and balanced effectiveness. The study also emphasizes the importance of organizational culture, data security, and system integration in MIS implementation. The research concludes that MIS is vital for business efficiency and effectiveness, but challenges such as data security and system integration require serious attention. The study recommends further research on in-depth case studies across industries to better understand the practical applications and specific challenges of MIS implementation.This research explores the evolving role of Management Information Systems (MIS) in the business world, focusing on its transformation from a data processing tool to a strategic catalyst that drives business model innovation and enhances organizational interactions with customers and competitors. The study highlights how MIS can be leveraged for innovation and differentiation while addressing challenges such as data security, system integration, and employee training. Using industry surveys and in-depth interviews with practitioners, the research aims to assess how MIS supports business strategy and operational decisions, and to identify and overcome implementation challenges. The findings are expected to provide practical guidance for business leaders and IT professionals, as well as contribute to academic literature on MIS in dynamic business environments. The study reveals that MIS plays a critical role in supporting business strategy and decision-making, and contributes to innovation and differentiation in competitive environments. Key findings include differences in MIS usage, effectiveness, and challenges based on company size, industry, and user experience. Startups have lower MIS usage, while SMEs show higher effectiveness. Large companies have higher usage and balanced effectiveness. The study also emphasizes the importance of organizational culture, data security, and system integration in MIS implementation. The research concludes that MIS is vital for business efficiency and effectiveness, but challenges such as data security and system integration require serious attention. The study recommends further research on in-depth case studies across industries to better understand the practical applications and specific challenges of MIS implementation.