This study investigates the role of Aurora kinase A (AURKA) in meningioma and its mechanism of action in promoting malignant characteristics and resistance to ferroptosis. AURKA was found to be upregulated in high-grade meningiomas and to enhance cell proliferation, inhibit apoptosis, and alter cell cycle progression. Mechanistically, AURKA was identified as a suppressor of erastin-induced ferroptosis by directly interacting with and phosphorylating Kelch-like ECH-associated protein 1 (KEAP1), thereby activating nuclear factor erythroid 2 related factor 2 (NFE2L2/NRF2) and downstream anti-ferroptotic genes. Additionally, forkhead box protein M1 (FOXM1) facilitated the transcription of AURKA. Suppression of AURKA, combined with erastin treatment, significantly improved the prognosis in a murine model of meningioma. The study highlights a novel mechanism by which AURKA governs ferroptosis and suggests that combining AURKA inhibition with ferroptosis-inducing agents could provide therapeutic benefits for meningioma treatment.This study investigates the role of Aurora kinase A (AURKA) in meningioma and its mechanism of action in promoting malignant characteristics and resistance to ferroptosis. AURKA was found to be upregulated in high-grade meningiomas and to enhance cell proliferation, inhibit apoptosis, and alter cell cycle progression. Mechanistically, AURKA was identified as a suppressor of erastin-induced ferroptosis by directly interacting with and phosphorylating Kelch-like ECH-associated protein 1 (KEAP1), thereby activating nuclear factor erythroid 2 related factor 2 (NFE2L2/NRF2) and downstream anti-ferroptotic genes. Additionally, forkhead box protein M1 (FOXM1) facilitated the transcription of AURKA. Suppression of AURKA, combined with erastin treatment, significantly improved the prognosis in a murine model of meningioma. The study highlights a novel mechanism by which AURKA governs ferroptosis and suggests that combining AURKA inhibition with ferroptosis-inducing agents could provide therapeutic benefits for meningioma treatment.