AURKA promotes ferroptosis resistance in meningioma through the FOXM1-AURKA-NRF2 axis. This study reveals that AURKA is upregulated in high-grade meningiomas and enhances their malignant characteristics. AURKA suppresses erastin-induced ferroptosis by interacting with and phosphorylating KEAP1, thereby activating NRF2 and its downstream anti-ferroptotic genes. Additionally, FOXM1 acts as a transcriptional factor for AURKA. The combination of AURKA inhibition and ferroptosis-inducing agents significantly improves the prognosis of a murine meningioma model. The study elucidates a novel mechanism by which AURKA regulates ferroptosis, suggesting that AURKA inhibition combined with ferroptosis-inducing agents could provide therapeutic benefits for meningioma treatment. AURKA activates the NRF2 pathway by inhibiting NRF2 ubiquitination and degradation, which is dependent on its kinase activity. AURKA directly interacts with KEAP1, which is involved in the regulation of NRF2 stability. These findings highlight the role of the FOXM1-AURKA-NRF2 axis in the regulation of ferroptosis in meningioma.AURKA promotes ferroptosis resistance in meningioma through the FOXM1-AURKA-NRF2 axis. This study reveals that AURKA is upregulated in high-grade meningiomas and enhances their malignant characteristics. AURKA suppresses erastin-induced ferroptosis by interacting with and phosphorylating KEAP1, thereby activating NRF2 and its downstream anti-ferroptotic genes. Additionally, FOXM1 acts as a transcriptional factor for AURKA. The combination of AURKA inhibition and ferroptosis-inducing agents significantly improves the prognosis of a murine meningioma model. The study elucidates a novel mechanism by which AURKA regulates ferroptosis, suggesting that AURKA inhibition combined with ferroptosis-inducing agents could provide therapeutic benefits for meningioma treatment. AURKA activates the NRF2 pathway by inhibiting NRF2 ubiquitination and degradation, which is dependent on its kinase activity. AURKA directly interacts with KEAP1, which is involved in the regulation of NRF2 stability. These findings highlight the role of the FOXM1-AURKA-NRF2 axis in the regulation of ferroptosis in meningioma.