This study examines mental health (MH) service utilization among parents of children with cancer compared to parents of children without cancer using nationwide commercial claims data. The research found that parents of children with cancer were more likely to seek MH services, including anxiety-related, depression-related, and any MH-related visits, than parents of children without cancer. The probabilities of these visits were significantly higher in families of children with cancer, with adjusted increases of 3.2 percentage points for anxiety-related visits, 2.2 percentage points for depression-related visits, and 4.2 percentage points for any MH-related visits. These differences were more pronounced among mothers than fathers. The study analyzed data from the Merative MarketScan Commercial Claims Database, which included 4837 families of children with cancer and 24,185 families of children without cancer. Most families had both parents identified, and the majority of families resided in urban areas. The study adjusted for sociodemographic and clinical factors, including parent age, child sex, and health plan type. It also considered factors such as the type of cancer and treatment modalities. The findings suggest that parents of children with cancer have higher MH care needs, highlighting the importance of targeted counseling and support to better meet their MH care needs. The study also found that mothers were more likely to seek MH services than fathers, and that factors such as urban residence and health plan type influenced MH service utilization. The study's results emphasize the need for interventions to address the mental health needs of parents and caregivers of children with cancer.This study examines mental health (MH) service utilization among parents of children with cancer compared to parents of children without cancer using nationwide commercial claims data. The research found that parents of children with cancer were more likely to seek MH services, including anxiety-related, depression-related, and any MH-related visits, than parents of children without cancer. The probabilities of these visits were significantly higher in families of children with cancer, with adjusted increases of 3.2 percentage points for anxiety-related visits, 2.2 percentage points for depression-related visits, and 4.2 percentage points for any MH-related visits. These differences were more pronounced among mothers than fathers. The study analyzed data from the Merative MarketScan Commercial Claims Database, which included 4837 families of children with cancer and 24,185 families of children without cancer. Most families had both parents identified, and the majority of families resided in urban areas. The study adjusted for sociodemographic and clinical factors, including parent age, child sex, and health plan type. It also considered factors such as the type of cancer and treatment modalities. The findings suggest that parents of children with cancer have higher MH care needs, highlighting the importance of targeted counseling and support to better meet their MH care needs. The study also found that mothers were more likely to seek MH services than fathers, and that factors such as urban residence and health plan type influenced MH service utilization. The study's results emphasize the need for interventions to address the mental health needs of parents and caregivers of children with cancer.