The article by Sidney A. Simon, a professor at Duke University, explores the challenges and mechanisms of multisensory integration, particularly in the context of taste processing. Simon highlights how the brain integrates information from different senses, such as taste, olfaction, and somatosensation, to make meaningful decisions and motor responses. He discusses the "binding problem," which is the process by which unimodal sensory inputs are combined to form a coherent percept. Simon suggests that the neocortex is likely multisensory and proposes the need for a detailed atlas of multisensory specificity in subcortical and cortical areas. He also emphasizes the importance of recording ensembles of neurons across different areas to better understand how multisensory integration occurs. The article references recent studies and reviews to support these points and calls for further research to advance our understanding of multisensory processing.The article by Sidney A. Simon, a professor at Duke University, explores the challenges and mechanisms of multisensory integration, particularly in the context of taste processing. Simon highlights how the brain integrates information from different senses, such as taste, olfaction, and somatosensation, to make meaningful decisions and motor responses. He discusses the "binding problem," which is the process by which unimodal sensory inputs are combined to form a coherent percept. Simon suggests that the neocortex is likely multisensory and proposes the need for a detailed atlas of multisensory specificity in subcortical and cortical areas. He also emphasizes the importance of recording ensembles of neurons across different areas to better understand how multisensory integration occurs. The article references recent studies and reviews to support these points and calls for further research to advance our understanding of multisensory processing.