The study presents the development of mesoporous non-precious metal (NPM) catalysts for the oxygen reduction reaction (ORR) in acidic media. The catalysts, including cobalt-nitrogen-doped carbon (C-N-Co) and iron-nitrogen-doped carbon (C-N-Fe), were synthesized using vitamin B12 (VB12) and polyaniline-Fe (PANI-Fe) complexes as precursors, respectively, with silica nanoparticles, ordered mesoporous silica SBA-15, and montmorillonite as templates. These templates were used to achieve well-defined mesoporous structures, which significantly enhanced the catalyst's performance. The most active catalyst, VB12/Silica colloid, exhibited a half-wave potential of 0.79 V, high selectivity (electron transfer number > 3.95), and excellent electrochemical stability (only 9 mV negative shift after 10,000 potential cycles). The superior performance of these NPM catalysts is attributed to their well-controlled porous structures, high Brunauer-Emmett-Teller (BET) surface area, and homogeneous distribution of metal-nitrogen active sites. This work demonstrates the potential of NPM catalysts for commercial viability in proton-exchange-membrane (PEM) fuel cells, offering a low-cost alternative to platinum-based catalysts.The study presents the development of mesoporous non-precious metal (NPM) catalysts for the oxygen reduction reaction (ORR) in acidic media. The catalysts, including cobalt-nitrogen-doped carbon (C-N-Co) and iron-nitrogen-doped carbon (C-N-Fe), were synthesized using vitamin B12 (VB12) and polyaniline-Fe (PANI-Fe) complexes as precursors, respectively, with silica nanoparticles, ordered mesoporous silica SBA-15, and montmorillonite as templates. These templates were used to achieve well-defined mesoporous structures, which significantly enhanced the catalyst's performance. The most active catalyst, VB12/Silica colloid, exhibited a half-wave potential of 0.79 V, high selectivity (electron transfer number > 3.95), and excellent electrochemical stability (only 9 mV negative shift after 10,000 potential cycles). The superior performance of these NPM catalysts is attributed to their well-controlled porous structures, high Brunauer-Emmett-Teller (BET) surface area, and homogeneous distribution of metal-nitrogen active sites. This work demonstrates the potential of NPM catalysts for commercial viability in proton-exchange-membrane (PEM) fuel cells, offering a low-cost alternative to platinum-based catalysts.