A meta-analysis of 74,046 individuals identified 11 new susceptibility loci for Alzheimer's disease. The study combined data from four genome-wide association studies (GWAS) in individuals of European ancestry, including 17,008 Alzheimer's disease cases and 37,154 controls in stage 1, and an independent set of 8,572 cases and 11,312 controls in stage 2. In addition to the APOE locus, 19 loci reached genome-wide significance, of which 11 were newly associated with Alzheimer's disease. The study confirmed the association of several known loci, including CLU, CR1, and CD33, and identified new loci such as HLA-DRB5–DRB1, SORL1, PTK2B, SLC24A4, ZCWPW1, CELF1, NME8, FERMT2, CASS4, and MEF2C. These loci are associated with various biological processes, including immune response, inflammation, synaptic function, cytoskeletal function, and microglial cell function. The study also highlighted the importance of the APOE gene as a major genetic risk factor for Alzheimer's disease. The results suggest that these new loci may contribute to the pathophysiology of Alzheimer's disease, and further research is needed to understand their exact roles. The study was supported by multiple funding sources and involved a large international collaboration.A meta-analysis of 74,046 individuals identified 11 new susceptibility loci for Alzheimer's disease. The study combined data from four genome-wide association studies (GWAS) in individuals of European ancestry, including 17,008 Alzheimer's disease cases and 37,154 controls in stage 1, and an independent set of 8,572 cases and 11,312 controls in stage 2. In addition to the APOE locus, 19 loci reached genome-wide significance, of which 11 were newly associated with Alzheimer's disease. The study confirmed the association of several known loci, including CLU, CR1, and CD33, and identified new loci such as HLA-DRB5–DRB1, SORL1, PTK2B, SLC24A4, ZCWPW1, CELF1, NME8, FERMT2, CASS4, and MEF2C. These loci are associated with various biological processes, including immune response, inflammation, synaptic function, cytoskeletal function, and microglial cell function. The study also highlighted the importance of the APOE gene as a major genetic risk factor for Alzheimer's disease. The results suggest that these new loci may contribute to the pathophysiology of Alzheimer's disease, and further research is needed to understand their exact roles. The study was supported by multiple funding sources and involved a large international collaboration.