This study investigates the association between biomarkers of carbohydrate, lipid, and apolipoprotein metabolism and the risk of depression, anxiety, and stress-related disorders. The research is based on a population-based cohort study with longitudinal data from 211,200 participants in the Apolipoprotein-Related Mortality Risk (AMORIS) cohort, who underwent occupational health screening between 1985 and 1996. The study used Cox proportional hazards regression models to examine the associations between biomarker levels and the risk of developing these psychiatric disorders over a mean follow-up period of 21 years. Key findings include: - High levels of glucose and triglycerides were associated with an increased risk of all tested psychiatric disorders. - High levels of high-density lipoprotein (HDL) were associated with a reduced risk. - These associations were consistent for both male and female participants and across all tested disorders. - Nested case-control analyses showed that patients with these disorders had higher levels of glucose, triglycerides, and total cholesterol during the 20 years preceding diagnosis, and higher levels of apolipoprotein A-I and apolipoprotein B during the 10 years preceding diagnosis compared to controls. The study suggests that elevated levels of glucose and triglycerides, and lower levels of HDL, are associated with an increased risk of depression, anxiety, and stress-related disorders. These findings support the idea that metabolic dysregulation may contribute to the development of common psychiatric disorders and highlight the importance of monitoring individuals with metabolic dysregulations for early prevention and diagnosis of psychiatric disorders.This study investigates the association between biomarkers of carbohydrate, lipid, and apolipoprotein metabolism and the risk of depression, anxiety, and stress-related disorders. The research is based on a population-based cohort study with longitudinal data from 211,200 participants in the Apolipoprotein-Related Mortality Risk (AMORIS) cohort, who underwent occupational health screening between 1985 and 1996. The study used Cox proportional hazards regression models to examine the associations between biomarker levels and the risk of developing these psychiatric disorders over a mean follow-up period of 21 years. Key findings include: - High levels of glucose and triglycerides were associated with an increased risk of all tested psychiatric disorders. - High levels of high-density lipoprotein (HDL) were associated with a reduced risk. - These associations were consistent for both male and female participants and across all tested disorders. - Nested case-control analyses showed that patients with these disorders had higher levels of glucose, triglycerides, and total cholesterol during the 20 years preceding diagnosis, and higher levels of apolipoprotein A-I and apolipoprotein B during the 10 years preceding diagnosis compared to controls. The study suggests that elevated levels of glucose and triglycerides, and lower levels of HDL, are associated with an increased risk of depression, anxiety, and stress-related disorders. These findings support the idea that metabolic dysregulation may contribute to the development of common psychiatric disorders and highlight the importance of monitoring individuals with metabolic dysregulations for early prevention and diagnosis of psychiatric disorders.