The supplementary figures and extended data figures in the article primarily focus on the use of histone H3 and α-tubulin as sample processing controls. These controls are used to ensure that the samples are processed consistently across different lanes of gels or membranes. The figures show that all blots, whether they are using pan Kac, histone H3, α-tubulin, or other specific antibodies, are run on separate gels using the same samples. Additionally, some figures detail specific experimental procedures, such as membrane cutting and incubation with different antibodies, to further validate the sample processing controls.The supplementary figures and extended data figures in the article primarily focus on the use of histone H3 and α-tubulin as sample processing controls. These controls are used to ensure that the samples are processed consistently across different lanes of gels or membranes. The figures show that all blots, whether they are using pan Kac, histone H3, α-tubulin, or other specific antibodies, are run on separate gels using the same samples. Additionally, some figures detail specific experimental procedures, such as membrane cutting and incubation with different antibodies, to further validate the sample processing controls.