Cancer metabolism, including carbohydrate, amino acid, and lipid metabolism, plays a crucial role in cancer progression and therapy. Ferroptosis, a regulated cell death induced by iron-dependent lipid peroxidation, is distinct from other forms of cell death. Cancer metabolism affects ferroptosis in both positive and negative ways. Carbohydrate metabolism provides NADPH to maintain GPX4 and FSP1 function, while amino acid metabolism supplies substrates for GPX4 synthesis. Lipid metabolism can synthesize PUFAs that trigger ferroptosis. The mechanisms by which cancer metabolism influences ferroptosis have been extensively studied, but some mechanisms remain unclear. This review summarizes the interaction between cancer metabolism and ferroptosis, focusing on potential targets for cancer therapy. Key findings include the role of glycolytic enzymes, amino acids like glutamate, glycine, and cysteine, and lipid metabolism in regulating ferroptosis. The review also highlights the potential of combining immunotherapy with ferroptosis-targeted therapy to improve cancer treatment outcomes.Cancer metabolism, including carbohydrate, amino acid, and lipid metabolism, plays a crucial role in cancer progression and therapy. Ferroptosis, a regulated cell death induced by iron-dependent lipid peroxidation, is distinct from other forms of cell death. Cancer metabolism affects ferroptosis in both positive and negative ways. Carbohydrate metabolism provides NADPH to maintain GPX4 and FSP1 function, while amino acid metabolism supplies substrates for GPX4 synthesis. Lipid metabolism can synthesize PUFAs that trigger ferroptosis. The mechanisms by which cancer metabolism influences ferroptosis have been extensively studied, but some mechanisms remain unclear. This review summarizes the interaction between cancer metabolism and ferroptosis, focusing on potential targets for cancer therapy. Key findings include the role of glycolytic enzymes, amino acids like glutamate, glycine, and cysteine, and lipid metabolism in regulating ferroptosis. The review also highlights the potential of combining immunotherapy with ferroptosis-targeted therapy to improve cancer treatment outcomes.