This paper reviews the applications of metal-based nanoparticles (NPs) in the treatment of cardiovascular diseases (CVDs). CVDs, including myocardial infarction, ischemic heart disease, and stroke, are leading causes of death and disability globally. Metal NPs, such as gold, silver, and iron, have shown promising potential in CVD management due to their unique physical, chemical, and biological properties. These NPs can be designed in various shapes and sizes, including nanoshells, nanorods, and nanospheres, and are used for molecular imaging, drug delivery, and enhancing radiation therapy. Iron oxide NPs (IONPs) are particularly useful for MRI contrast enhancement and targeted drug delivery, while gold NPs (AuNPs) are effective in cardiovascular imaging and therapeutic platforms. Silver NPs (AgNPs) exhibit antimicrobial and anti-inflammatory effects, and cerium oxide NPs (CeO$_2$ NPs) have antioxidant properties that can reduce oxidative stress in CVDs. However, the safety and toxicity of these NPs need further investigation, as they can cause adverse effects such as oxidative stress, inflammation, and microvascular dysfunction. The paper highlights the need for more research to fully understand the mechanisms and potential benefits of using metal NPs in CVD treatment.This paper reviews the applications of metal-based nanoparticles (NPs) in the treatment of cardiovascular diseases (CVDs). CVDs, including myocardial infarction, ischemic heart disease, and stroke, are leading causes of death and disability globally. Metal NPs, such as gold, silver, and iron, have shown promising potential in CVD management due to their unique physical, chemical, and biological properties. These NPs can be designed in various shapes and sizes, including nanoshells, nanorods, and nanospheres, and are used for molecular imaging, drug delivery, and enhancing radiation therapy. Iron oxide NPs (IONPs) are particularly useful for MRI contrast enhancement and targeted drug delivery, while gold NPs (AuNPs) are effective in cardiovascular imaging and therapeutic platforms. Silver NPs (AgNPs) exhibit antimicrobial and anti-inflammatory effects, and cerium oxide NPs (CeO$_2$ NPs) have antioxidant properties that can reduce oxidative stress in CVDs. However, the safety and toxicity of these NPs need further investigation, as they can cause adverse effects such as oxidative stress, inflammation, and microvascular dysfunction. The paper highlights the need for more research to fully understand the mechanisms and potential benefits of using metal NPs in CVD treatment.