The article reviews the potential of metal nanoparticles (MNPs) in treating diabetic wounds, highlighting their anti-inflammatory, antioxidant, antibacterial, and pro-angiogenic properties. MNPs can stimulate the expression of proteins that promote wound healing and serve as drug delivery systems for small-molecule drugs. By combining MNPs with other biomaterials like hydrogels and chitosan, novel dressings can be developed to revolutionize the treatment of diabetic wounds. The article discusses the underlying mechanisms of diabetic wound healing, including the role of macrophages and angiogenesis, and explores the clinical applications and future prospects of MNPs in diabetic wound management. Key MNPs such as AuNPs, AgNPs, and CuNPs are reviewed, focusing on their antibacterial mechanisms, drug delivery capabilities, and their ability to enhance wound healing through various therapeutic mechanisms. The article concludes that MNPs represent a promising strategy for treating diabetic wounds, with future research directions including the development of new biological dressings and the exploration of additional physicochemical properties of MNPs to further improve wound healing.The article reviews the potential of metal nanoparticles (MNPs) in treating diabetic wounds, highlighting their anti-inflammatory, antioxidant, antibacterial, and pro-angiogenic properties. MNPs can stimulate the expression of proteins that promote wound healing and serve as drug delivery systems for small-molecule drugs. By combining MNPs with other biomaterials like hydrogels and chitosan, novel dressings can be developed to revolutionize the treatment of diabetic wounds. The article discusses the underlying mechanisms of diabetic wound healing, including the role of macrophages and angiogenesis, and explores the clinical applications and future prospects of MNPs in diabetic wound management. Key MNPs such as AuNPs, AgNPs, and CuNPs are reviewed, focusing on their antibacterial mechanisms, drug delivery capabilities, and their ability to enhance wound healing through various therapeutic mechanisms. The article concludes that MNPs represent a promising strategy for treating diabetic wounds, with future research directions including the development of new biological dressings and the exploration of additional physicochemical properties of MNPs to further improve wound healing.