Metal nanoparticles (MNPs) have shown great potential in promoting diabetic wound healing due to their antimicrobial, antioxidant, and pro-angiogenic properties. MNPs can stimulate the expression of proteins that promote wound healing and serve as drug delivery systems for small-molecule drugs. By combining MNPs with other biomaterials such as hydrogels and chitosan, novel dressings can be developed to revolutionize the treatment of diabetic wounds. MNPs also facilitate intelligent drug release, such as the ability to be externally triggered by infrared radiation or magnetic fields, thereby achieving multi-stimulus-responsive drug release. This property provides effective targeting to the complex healing process of diabetic wounds, allowing progress toward accelerated healing at different stages of wound healing. The unique physicochemical properties of MNPs have attracted more and more attention in the study of diabetic wound healing. However, a comprehensive and systematic review is lacking. This review provides a comprehensive overview of the research progress on the utilization of MNPs for treating diabetic wounds. It summarizes the underlying mechanisms involved in diabetic wound healing and discusses the potential application of MNPs as biomaterials for drug delivery. Furthermore, it provides an extensive analysis and discussion on the clinical implementation of dressings, while also highlighting future prospects for utilizing MNPs in diabetic wound management. In conclusion, MNPs represent a promising strategy for the treatment of diabetic wound healing. Future directions include combining other biological nanomaterials to synthesize new biological dressings or utilizing the other physicochemical properties of MNPs to promote wound healing. Synthetic biomaterials that contain MNPs not only play a role in all stages of diabetic wound healing, but also provide a stable physiological environment for the wound-healing process.Metal nanoparticles (MNPs) have shown great potential in promoting diabetic wound healing due to their antimicrobial, antioxidant, and pro-angiogenic properties. MNPs can stimulate the expression of proteins that promote wound healing and serve as drug delivery systems for small-molecule drugs. By combining MNPs with other biomaterials such as hydrogels and chitosan, novel dressings can be developed to revolutionize the treatment of diabetic wounds. MNPs also facilitate intelligent drug release, such as the ability to be externally triggered by infrared radiation or magnetic fields, thereby achieving multi-stimulus-responsive drug release. This property provides effective targeting to the complex healing process of diabetic wounds, allowing progress toward accelerated healing at different stages of wound healing. The unique physicochemical properties of MNPs have attracted more and more attention in the study of diabetic wound healing. However, a comprehensive and systematic review is lacking. This review provides a comprehensive overview of the research progress on the utilization of MNPs for treating diabetic wounds. It summarizes the underlying mechanisms involved in diabetic wound healing and discusses the potential application of MNPs as biomaterials for drug delivery. Furthermore, it provides an extensive analysis and discussion on the clinical implementation of dressings, while also highlighting future prospects for utilizing MNPs in diabetic wound management. In conclusion, MNPs represent a promising strategy for the treatment of diabetic wound healing. Future directions include combining other biological nanomaterials to synthesize new biological dressings or utilizing the other physicochemical properties of MNPs to promote wound healing. Synthetic biomaterials that contain MNPs not only play a role in all stages of diabetic wound healing, but also provide a stable physiological environment for the wound-healing process.