The article reviews the antimicrobial properties of metallic copper surfaces, which have been observed to rapidly kill bacteria, yeasts, and viruses through a process known as "contact killing." This phenomenon, which has been known since ancient times, is now receiving renewed attention due to its potential use in healthcare settings to combat nosocomial infections. The antimicrobial activity of copper and copper alloys is well-established, and copper has been registered as the first solid antimicrobial material by the U.S. Environmental Protection Agency. Clinical studies have shown that copper surfaces can reduce bacterial counts on touch surfaces such as door handles, bathroom fixtures, and bed rails. The article discusses the mechanisms of contact killing, which involve the release of dissolved copper ions from the surface, leading to cell damage, membrane rupture, and the generation of reactive oxygen species. Bacterial resistance systems do not protect against contact killing but can prolong survival. The antimicrobial properties of copper surfaces are maintained even when soiled, and cleaning protocols should be designed to preserve their efficacy. Hospital trials have demonstrated that copper surfaces can significantly reduce bacterial counts, indicating their potential as an additional tool to control hospital-acquired infections. However, long-term studies are needed to evaluate the sustainability of these antimicrobial properties over several years. The article also addresses the challenges of spore-forming bacteria and the need for further research to integrate copper surfaces with other disinfection methods and hygiene practices in healthcare facilities.The article reviews the antimicrobial properties of metallic copper surfaces, which have been observed to rapidly kill bacteria, yeasts, and viruses through a process known as "contact killing." This phenomenon, which has been known since ancient times, is now receiving renewed attention due to its potential use in healthcare settings to combat nosocomial infections. The antimicrobial activity of copper and copper alloys is well-established, and copper has been registered as the first solid antimicrobial material by the U.S. Environmental Protection Agency. Clinical studies have shown that copper surfaces can reduce bacterial counts on touch surfaces such as door handles, bathroom fixtures, and bed rails. The article discusses the mechanisms of contact killing, which involve the release of dissolved copper ions from the surface, leading to cell damage, membrane rupture, and the generation of reactive oxygen species. Bacterial resistance systems do not protect against contact killing but can prolong survival. The antimicrobial properties of copper surfaces are maintained even when soiled, and cleaning protocols should be designed to preserve their efficacy. Hospital trials have demonstrated that copper surfaces can significantly reduce bacterial counts, indicating their potential as an additional tool to control hospital-acquired infections. However, long-term studies are needed to evaluate the sustainability of these antimicrobial properties over several years. The article also addresses the challenges of spore-forming bacteria and the need for further research to integrate copper surfaces with other disinfection methods and hygiene practices in healthcare facilities.