The article provides a comprehensive overview of methicillin-resistant *Staphylococcus aureus* (MRSA), a significant global health concern. MRSA emerged in the 1960s and has since spread worldwide, causing a wide range of infections in both healthcare and community settings. The burden of MRSA varies geographically, influenced by factors such as infection control practices and pathogen characteristics. MRSA is often resistant to multiple antibiotics, making treatment challenging. The article discusses the epidemiology, pathophysiology, diagnosis, prevention, management, and clinical effects of MRSA, focusing on healthcare-associated MRSA (HA-MRSA). It highlights the importance of understanding colonization dynamics, transmission routes, risk factors, and conditions promoting resistance to optimize control strategies. The article also mentions the development of new antimicrobials and vaccines as potential solutions. Additionally, it covers the mechanisms of methicillin resistance, including the acquisition of the staphylococcal cassette chromosome $mec$ (SCC$mec$), and the role of virulence factors in infection. Finally, it discusses diagnostic methods, including phenotypic and genotypic techniques, and the challenges and advancements in microbiological diagnosis.The article provides a comprehensive overview of methicillin-resistant *Staphylococcus aureus* (MRSA), a significant global health concern. MRSA emerged in the 1960s and has since spread worldwide, causing a wide range of infections in both healthcare and community settings. The burden of MRSA varies geographically, influenced by factors such as infection control practices and pathogen characteristics. MRSA is often resistant to multiple antibiotics, making treatment challenging. The article discusses the epidemiology, pathophysiology, diagnosis, prevention, management, and clinical effects of MRSA, focusing on healthcare-associated MRSA (HA-MRSA). It highlights the importance of understanding colonization dynamics, transmission routes, risk factors, and conditions promoting resistance to optimize control strategies. The article also mentions the development of new antimicrobials and vaccines as potential solutions. Additionally, it covers the mechanisms of methicillin resistance, including the acquisition of the staphylococcal cassette chromosome $mec$ (SCC$mec$), and the role of virulence factors in infection. Finally, it discusses diagnostic methods, including phenotypic and genotypic techniques, and the challenges and advancements in microbiological diagnosis.