A study of 26 regional pig farmers in the Netherlands found a methicillin-resistant Staphylococcus aureus (MRSA) prevalence rate more than 760 times higher than that of patients admitted to Dutch hospitals. The study identified three different MRSA strains, including a new spa-type (t108), which was widespread among pig farmers and their environment. The strain was found in a 6-month-old girl, her parents, and pigs on their farm. Subsequent cases included a pig farmer from a different region and a son of a veterinarian who worked with pigs. The strain was also isolated from a nurse who treated the son. All isolates were resistant to digestion with restriction endonuclease SmaI, and genotyping confirmed they were not typeable by pulsed-field gel electrophoresis. The study suggests that pig farming may be a source of MRSA transmission between animals and humans, as well as among family members and healthcare workers. The high prevalence among pig farmers indicates that their profession may put them at risk for MRSA colonization. Further research is needed to determine if these findings are applicable in other regions. If so, pig farming could be a significant risk factor for MRSA carriage in humans, warranting screening for pig farmers and their family members when admitted to hospitals.A study of 26 regional pig farmers in the Netherlands found a methicillin-resistant Staphylococcus aureus (MRSA) prevalence rate more than 760 times higher than that of patients admitted to Dutch hospitals. The study identified three different MRSA strains, including a new spa-type (t108), which was widespread among pig farmers and their environment. The strain was found in a 6-month-old girl, her parents, and pigs on their farm. Subsequent cases included a pig farmer from a different region and a son of a veterinarian who worked with pigs. The strain was also isolated from a nurse who treated the son. All isolates were resistant to digestion with restriction endonuclease SmaI, and genotyping confirmed they were not typeable by pulsed-field gel electrophoresis. The study suggests that pig farming may be a source of MRSA transmission between animals and humans, as well as among family members and healthcare workers. The high prevalence among pig farmers indicates that their profession may put them at risk for MRSA colonization. Further research is needed to determine if these findings are applicable in other regions. If so, pig farming could be a significant risk factor for MRSA carriage in humans, warranting screening for pig farmers and their family members when admitted to hospitals.