MiRNA in cervical cancer: Diagnosis to therapy: Systematic review

MiRNA in cervical cancer: Diagnosis to therapy: Systematic review

12 January 2024 | Hiwot Tezera Endale, Yitbarek Fantahun Mariye, Habtu Kifle Negash, Fethiya Seid Hassen, Wastina Bitewlign Asrat, Tiget Ayelgn Mengstie, Winta Tesfaye
This review article explores the role of microRNAs (miRNAs) in cervical cancer, focusing on their diagnostic and therapeutic potential. Cervical cancer, the fourth most common cancer among women globally, is primarily associated with Human papillomavirus (HPV) infection. Epigenetic changes, including DNA methylation and histone modifications, play a crucial role in cervical cancer development and progression. MiRNAs, small non-coding RNAs, are involved in regulating gene expression and have been identified as potential biomarkers for cervical cancer diagnosis and prognosis. The article discusses the biogenesis of miRNAs, their targets, and their involvement in various signaling pathways such as the PI3K/AKT, Hedgehog, p38/MAPK, Wnt/β-catenin, and TGFβ pathways. It also highlights the dysregulation of miRNAs in cervical cancer, particularly in high-risk HPV-positive cases, and their impact on drug resistance. The review concludes by discussing the potential of miRNAs as biomarkers and therapeutic targets for cervical cancer, emphasizing the need for further research to develop molecularly targeted therapies.This review article explores the role of microRNAs (miRNAs) in cervical cancer, focusing on their diagnostic and therapeutic potential. Cervical cancer, the fourth most common cancer among women globally, is primarily associated with Human papillomavirus (HPV) infection. Epigenetic changes, including DNA methylation and histone modifications, play a crucial role in cervical cancer development and progression. MiRNAs, small non-coding RNAs, are involved in regulating gene expression and have been identified as potential biomarkers for cervical cancer diagnosis and prognosis. The article discusses the biogenesis of miRNAs, their targets, and their involvement in various signaling pathways such as the PI3K/AKT, Hedgehog, p38/MAPK, Wnt/β-catenin, and TGFβ pathways. It also highlights the dysregulation of miRNAs in cervical cancer, particularly in high-risk HPV-positive cases, and their impact on drug resistance. The review concludes by discussing the potential of miRNAs as biomarkers and therapeutic targets for cervical cancer, emphasizing the need for further research to develop molecularly targeted therapies.
Reach us at info@study.space
[slides and audio] MiRNA in cervical cancer%3A Diagnosis to therapy%3A Systematic review