The article "MicroRNAs in Cancer: Small Molecules With a Huge Impact" by Marilena V. Iorio and Carlo M. Croce reviews the role of microRNAs (miRNAs) in cancer. MiRNAs are small non-coding RNA molecules that play crucial roles in regulating gene expression, and their dysregulation is a hallmark of several diseases, including cancer. The authors highlight how miRNAs can function as both oncogenes and oncosuppressors, depending on the cellular context and the target genes they regulate. They discuss the involvement of miRNAs in various aspects of cancer, such as diagnosis, prognosis, and therapy. The article also covers the biogenesis, processing, and maturation of miRNAs, as well as their mechanisms of action in regulating gene expression. Additionally, it explores the impact of miRNAs on invasion, angiogenesis, and metastasis, and their potential as therapeutic targets. The authors emphasize the importance of miRNAs in maintaining cellular balance and the consequences of their deregulation in cancer development and progression. They conclude by discussing the challenges and future directions in using miRNAs as diagnostic, prognostic, and therapeutic tools in cancer research.The article "MicroRNAs in Cancer: Small Molecules With a Huge Impact" by Marilena V. Iorio and Carlo M. Croce reviews the role of microRNAs (miRNAs) in cancer. MiRNAs are small non-coding RNA molecules that play crucial roles in regulating gene expression, and their dysregulation is a hallmark of several diseases, including cancer. The authors highlight how miRNAs can function as both oncogenes and oncosuppressors, depending on the cellular context and the target genes they regulate. They discuss the involvement of miRNAs in various aspects of cancer, such as diagnosis, prognosis, and therapy. The article also covers the biogenesis, processing, and maturation of miRNAs, as well as their mechanisms of action in regulating gene expression. Additionally, it explores the impact of miRNAs on invasion, angiogenesis, and metastasis, and their potential as therapeutic targets. The authors emphasize the importance of miRNAs in maintaining cellular balance and the consequences of their deregulation in cancer development and progression. They conclude by discussing the challenges and future directions in using miRNAs as diagnostic, prognostic, and therapeutic tools in cancer research.